Chung-Han Hsin1,2, Hsien-Chun Tseng2,3, Huang-Pin Lin1,2, Tsai-Hsin Chen2,4. 1. Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan. 2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 3. Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan. 4. Department of Anesthesiology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Abstract
BACKGROUND: Sinus mucosa abnormalities on image studies, which is the major diagnostic measure for sinusitis, were investigated in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). METHODS: A retrospective review of the MRIs for patients with NPC was conducted. Sinus mucosa abnormalities were staged by the Lund-Mackay system. RESULTS: A total of 94 patients were enrolled in this study. The rate and severity of sinus abnormalities were highest on the third postradiotherapy month (p < .005, t test). There was no significant increase in the incidence of abnormalities on the fifth postradiotherapy year (t test). The anterior ethmoid and maxillary sinuses were the most affected sinuses before and after radiotherapy (p < .005, chi-square test). CONCLUSION: Our data showed that the anterior ethmoid and maxillary sinuses were the most vulnerable sinuses for therapeutic toxicity after IMRT in patients with NPC. In the long run, however, the application of IMRT does not significantly increase the incidence of sinus toxicities.
BACKGROUND:Sinus mucosa abnormalities on image studies, which is the major diagnostic measure for sinusitis, were investigated in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). METHODS: A retrospective review of the MRIs for patients with NPC was conducted. Sinus mucosa abnormalities were staged by the Lund-Mackay system. RESULTS: A total of 94 patients were enrolled in this study. The rate and severity of sinus abnormalities were highest on the third postradiotherapy month (p < .005, t test). There was no significant increase in the incidence of abnormalities on the fifth postradiotherapy year (t test). The anterior ethmoid and maxillary sinuses were the most affected sinuses before and after radiotherapy (p < .005, chi-square test). CONCLUSION: Our data showed that the anterior ethmoid and maxillary sinuses were the most vulnerable sinuses for therapeutic toxicity after IMRT in patients with NPC. In the long run, however, the application of IMRT does not significantly increase the incidence of sinus toxicities.
Authors: Maria Silvia Lazio; Angelo Cannavicci; Massimo Squadrelli Saraceno; Giandomenico Maggiore Journal: Indian J Otolaryngol Head Neck Surg Date: 2018-03-29
Authors: Alicja I Reczynska; Susan M LaRue; Mary-Keara Boss; Ber-In Lee; Del Leary; Kelsey Pohlmann; Lynn Griffin; Susan Lana; Tiffany Wormhoudt Martin Journal: J Vet Intern Med Date: 2022-02-21 Impact factor: 3.333