Literature DB >> 25196617

Cerebellar mass as a location of acute lymphoblastic leukaemia.

Ilaria Desideri1, Silvia Canovetti2, Ilaria Pesaresi3, Michele Caniglia2, Eugenio Ciancia4, Carlo Bartolozzi2, Michele Puglioli3, Mirco Cosottini5.   

Abstract

A 22-year-old man with acute lymphoblastic leukaemia was referred to our observation for headache, cervical pain and sopor. A computed tomography study revealed triventricular obstructive hydrocephalus due to a left cerebellar hyperdense mass impinging on the fourth ventricle. A magnetic resonance study demonstrated an area of hyperintensity on T2-weighted images, hypointensity on T1, restricted diffusivity and contrast enhancement involving the left hemispherical cerebellar cortex and the vermis and causing cerebellar herniation. After surgical excision of the lesion, histological examination revealed an infiltrate of lymphoblastic leukaemia with B cells. Leukaemic intracranial masses are rare. Our report describes a case presenting a cerebellar mass of leukaemic tissue characterized by high cellularity and low apparent diffusion coefficient value comparable to acute ischaemia. Therefore leukaemic intracranial mass has to be considered in the differential diagnosis of cerebellar masses.

Entities:  

Keywords:  MRI; acute lymphoblastic leukaemia; apparent diffusion coefficient; cerebellar mass

Mesh:

Year:  2014        PMID: 25196617      PMCID: PMC4236863          DOI: 10.15274/NRJ-2014-10069

Source DB:  PubMed          Journal:  Neuroradiol J        ISSN: 1971-4009


  10 in total

1.  Diffusion-weighted imaging of primary brain lymphomas: effect of ADC value and signal intensity of T2-weighted imaging.

Authors:  Masuma Akter; Toshinori Hirai; Keishi Makino; Mika Kitajima; Ryuji Murakami; Hirofumi Fukuoka; Akira Sasao; Jun-ichi Kuratsu; Yasuyuki Yamashita
Journal:  Comput Med Imaging Graph       Date:  2008-07-09       Impact factor: 4.790

2.  The role of diffusion-weighted imaging in patients with brain tumors.

Authors:  K Kono; Y Inoue; K Nakayama; M Shakudo; M Morino; K Ohata; K Wakasa; R Yamada
Journal:  AJNR Am J Neuroradiol       Date:  2001 Jun-Jul       Impact factor: 3.825

3.  The incidence of central nervous system leukemia in adults with acute leukemia.

Authors:  R W Wolk; S R Masse; R Conklin; E J Freireich
Journal:  Cancer       Date:  1974-03       Impact factor: 6.860

4.  Value of diffusion-weighted imaging and apparent diffusion coefficient in recent cerebral infarctions: a correlative study with contrast-enhanced T1-weighted imaging.

Authors:  N Yamada; S Imakita; T Sakuma
Journal:  AJNR Am J Neuroradiol       Date:  1999-02       Impact factor: 3.825

Review 5.  Neuroimaging in pediatric leukemia and lymphoma: differential diagnosis.

Authors:  Elida Vázquez; Javier Lucaya; Amparo Castellote; Joaquim Piqueras; Pilar Sainz; Teresa Olivé; José Sánchez-Toledo; Juan J Ortega
Journal:  Radiographics       Date:  2002 Nov-Dec       Impact factor: 5.333

Review 6.  Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature.

Authors:  Tuncer Suzer; Nagihan Colakoglu; Bayram Cirak; Ali Keskin; Erdal Coskun; Kadir Tahta
Journal:  J Clin Neurosci       Date:  2004-11       Impact factor: 1.961

Review 7.  Neuroradiology of leukemia.

Authors:  L E Ginsberg; N E Leeds
Journal:  AJR Am J Roentgenol       Date:  1995-09       Impact factor: 3.959

8.  MRI of central nervous system abnormalities in childhood leukemia.

Authors:  Esra Meltem Kayahan Ulu; Hüseyin Gürkan Töre; Ahmet Bayrak; Durmuş Güngör; Mehmet Coşkun
Journal:  Diagn Interv Radiol       Date:  2009-06       Impact factor: 2.630

9.  Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient.

Authors:  E J Lee; S K Lee; R Agid; J M Bae; A Keller; K Terbrugge
Journal:  AJNR Am J Neuroradiol       Date:  2008-08-21       Impact factor: 3.825

10.  Leukemic infiltration of the cerebellum in acute myelomonocytic leukemia.

Authors:  C B Saper; C I Jarowski
Journal:  Neurology       Date:  1982-01       Impact factor: 9.910

  10 in total

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