| Literature DB >> 25196100 |
Teresa Costa Castanho1, Pedro Silva Moreira1, Carlos Portugal-Nunes1, Ashley Novais1, Patrício Soares Costa1, Joana Almeida Palha1, Nuno Sousa1, Nadine Correia Santos2.
Abstract
Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.Entities:
Keywords: Executive function; Memory; Nutrition; Quality of life; Sleep
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Year: 2014 PMID： 25196100 DOI： 10.1016/j.biopsycho.2014.08.015
Source DB: PubMed Journal: Biol Psychol ISSN： 0301-0511 Impact factor: 3.251