BACKGROUND/AIMS: Deposits of phosphorylated tau protein and convergence of pathology in the hippocampus are the hallmarks of neurodegenerative tauopathies. Thus we aimed to evaluate whether regional and cellular vulnerability patterns in the hippocampus distinguish tauopathies or are influenced by their concomitant presence. METHODS: We created a heat map of phospho-tau (AT8) immunoreactivity patterns in 24 hippocampal subregions/layers in individuals with Alzheimer's disease (AD)-related neurofibrillary degeneration (n = 40), Pick's disease (n = 8), progressive supranuclear palsy (n = 7), corticobasal degeneration (n = 6), argyrophilic grain disease (AGD, n = 18), globular glial tauopathy (n = 5), and tau-astrogliopathy of the elderly (n = 10). AT8 immunoreactivity patterns were compared by mathematical analysis. RESULTS: Our study reveals disease-specific hot spots and regional selective vulnerability for these disorders. The pattern of hippocampal AD-related tau pathology is strongly influenced by concomitant AGD. Mathematical analysis reveals that hippocampal involvement in primary tauopathies is distinguishable from early-stage AD-related neurofibrillary degeneration. CONCLUSION: Our data demonstrate disease-specific AT8 immunoreactivity patterns and hot spots in the hippocampus even in tauopathies, which primarily do not affect the hippocampus. These hot spots can be shifted to other regions by the co-occurrence of tauopathies like AGD. Our observations support the notion that globular glial tauopathies and tau-astrogliopathy of the elderly are distinct entities.
BACKGROUND/AIMS: Deposits of phosphorylated tau protein and convergence of pathology in the hippocampus are the hallmarks of neurodegenerative tauopathies. Thus we aimed to evaluate whether regional and cellular vulnerability patterns in the hippocampus distinguish tauopathies or are influenced by their concomitant presence. METHODS: We created a heat map of phospho-tau (AT8) immunoreactivity patterns in 24 hippocampal subregions/layers in individuals with Alzheimer's disease (AD)-related neurofibrillary degeneration (n = 40), Pick's disease (n = 8), progressive supranuclear palsy (n = 7), corticobasal degeneration (n = 6), argyrophilic grain disease (AGD, n = 18), globular glial tauopathy (n = 5), and tau-astrogliopathy of the elderly (n = 10). AT8 immunoreactivity patterns were compared by mathematical analysis. RESULTS: Our study reveals disease-specific hot spots and regional selective vulnerability for these disorders. The pattern of hippocampal AD-related tau pathology is strongly influenced by concomitant AGD. Mathematical analysis reveals that hippocampal involvement in primary tauopathies is distinguishable from early-stage AD-related neurofibrillary degeneration. CONCLUSION: Our data demonstrate disease-specific AT8 immunoreactivity patterns and hot spots in the hippocampus even in tauopathies, which primarily do not affect the hippocampus. These hot spots can be shifted to other regions by the co-occurrence of tauopathies like AGD. Our observations support the notion that globular glial tauopathies and tau-astrogliopathy of the elderly are distinct entities.
Authors: Gabor G Kovacs; Linda K Kwong; Murray Grossman; David J Irwin; Edward B Lee; John L Robinson; Eunran Suh; Vivianna M Van Deerlin; Virginia M Lee; John Q Trojanowski Journal: Brain Pathol Date: 2017-01-19 Impact factor: 6.508
Authors: Peter T Nelson; Erin L Abner; Ela Patel; Sonya Anderson; Donna M Wilcock; Richard J Kryscio; Linda J Van Eldik; Gregory A Jicha; Zsombor Gal; Ruth S Nelson; Bela G Nelson; Jozsef Gal; Md Tofial Azam; David W Fardo; Matthew D Cykowski Journal: J Neuropathol Exp Neurol Date: 2018-01-01 Impact factor: 3.685
Authors: Kurt Farrell; Megan A Iida; Jonathan D Cherry; Alicia Casella; Thor D Stein; Kevin F Bieniek; Jamie M Walker; Timothy E Richardson; Charles L White; Victor E Alvarez; Bertrand R Huber; Dennis W Dickson; Ricardo Insausti; Kristen Dams-O'Connor; Ann C McKee; John F Crary Journal: J Neuropathol Exp Neurol Date: 2022-09-19 Impact factor: 3.148
Authors: Gabor G Kovacs; Isidro Ferrer; Lea T Grinberg; Irina Alafuzoff; Johannes Attems; Herbert Budka; Nigel J Cairns; John F Crary; Charles Duyckaerts; Bernardino Ghetti; Glenda M Halliday; James W Ironside; Seth Love; Ian R Mackenzie; David G Munoz; Melissa E Murray; Peter T Nelson; Hitoshi Takahashi; John Q Trojanowski; Olaf Ansorge; Thomas Arzberger; Atik Baborie; Thomas G Beach; Kevin F Bieniek; Eileen H Bigio; Istvan Bodi; Brittany N Dugger; Mel Feany; Ellen Gelpi; Stephen M Gentleman; Giorgio Giaccone; Kimmo J Hatanpaa; Richard Heale; Patrick R Hof; Monika Hofer; Tibor Hortobágyi; Kurt Jellinger; Gregory A Jicha; Paul Ince; Julia Kofler; Enikö Kövari; Jillian J Kril; David M Mann; Radoslav Matej; Ann C McKee; Catriona McLean; Ivan Milenkovic; Thomas J Montine; Shigeo Murayama; Edward B Lee; Jasmin Rahimi; Roberta D Rodriguez; Annemieke Rozemüller; Julie A Schneider; Christian Schultz; William Seeley; Danielle Seilhean; Colin Smith; Fabrizio Tagliavini; Masaki Takao; Dietmar Rudolf Thal; Jon B Toledo; Markus Tolnay; Juan C Troncoso; Harry V Vinters; Serge Weis; Stephen B Wharton; Charles L White; Thomas Wisniewski; John M Woulfe; Masahito Yamada; Dennis W Dickson Journal: Acta Neuropathol Date: 2015-12-10 Impact factor: 17.088
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Authors: Jamie M Walker; Timothy E Richardson; Kurt Farrell; Megan A Iida; Chan Foong; Ping Shang; Johannes Attems; Gai Ayalon; Thomas G Beach; Eileen H Bigio; Andrew Budson; Nigel J Cairns; María Corrada; Etty Cortes; Dennis W Dickson; Peter Fischer; Margaret E Flanagan; Erin Franklin; Marla Gearing; Jonathan Glass; Lawrence A Hansen; Vahram Haroutunian; Patrick R Hof; Lawrence Honig; Claudia Kawas; C Dirk Keene; Julia Kofler; Gabor G Kovacs; Edward B Lee; Mirjam I Lutz; Qinwen Mao; Eliezer Masliah; Ann C McKee; Corey T McMillan; M Marsel Mesulam; Melissa Murray; Peter T Nelson; Richard Perrin; Thao Pham; Wayne Poon; Dushyant P Purohit; Robert A Rissman; Kenji Sakai; Mary Sano; Julie A Schneider; Thor D Stein; Andrew F Teich; John Q Trojanowski; Juan C Troncoso; Jean-Paul Vonsattel; Sandra Weintraub; David A Wolk; Randall L Woltjer; Masahito Yamada; Lei Yu; Charles L White; John F Crary Journal: J Neuropathol Exp Neurol Date: 2021-01-20 Impact factor: 3.148
Authors: Stephen P Arnerić; Richard Batrla-Utermann; Laurel Beckett; Tobias Bittner; Kaj Blennow; Leslie Carter; Robert Dean; Sebastiaan Engelborghs; Just Genius; Mark Forrest Gordon; Janice Hitchcock; June Kaplow; Johan Luthman; Richard Meibach; David Raunig; Klaus Romero; Mahesh N Samtani; Mary Savage; Leslie Shaw; Diane Stephenson; Robert M Umek; Hugo Vanderstichele; Brian Willis; Susan Yule Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472