Carmen Natal1, Martín Caicoya2, Miguel Prieto2, Adonina Tardón3. 1. Servicio de Salud del Principado de Asturias, Oviedo, Asturias, España. Electronic address: carmen.natal@sespa.princast.es. 2. Consejería de Sanidad del Principado de Asturias, Oviedo, Asturias, España. 3. Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Asturias, España.
Abstract
OBJECTIVE: To compare breast cancer cumulative incidence, time evolution and stage at diagnosis between participants and non-participant women in a population-based screening program. METHODS: Cohort study of breast cancer incidence in relation to participation in a population screening program. The study population included women from the target population of the screening program. The source of information for diagnostics and stages was the population-based cancer registry. The analysis period was 1999-2010. RESULTS: The Relative Risk for invasive, in situ, and total cancers diagnosed in participant women compared with non-participants were respectively 1.16 (0.94-1.43), 2.98 (1.16-7.62) and 1.22 (0.99-1.49). The Relative Risk for participants versus non-participants was 2.47 (1.55-3.96) for diagnosis at stagei, 2.58 (1.67-3.99) for T1 and 2.11 (1.38-3.23) for negative lymph node involvement. The cumulative incidence trend had two joint points in both arms, with an Annual Percent of Change of 92.3 (81.6-103.5) between 1999-2001, 18.2 (16.1-20.3) between 2001-2005 and 5.9 (4.0-7.8) for the last period in participants arm, and 72.6 (58.5-87.9) between 1999-2001, 12.6 (7.9-17.4) between 2001-2005, and 8.6 (6.5-10.6) in the last period in the non-participant arm. CONCLUSIONS: Participating in the breast cancer screening program analyzed increased the in situ cumulative cancer incidence, but not the invasive and total incidence. Diagnoses were earlier in the participant arm.
OBJECTIVE: To compare breast cancer cumulative incidence, time evolution and stage at diagnosis between participants and non-participantwomen in a population-based screening program. METHODS: Cohort study of breast cancer incidence in relation to participation in a population screening program. The study population included women from the target population of the screening program. The source of information for diagnostics and stages was the population-based cancer registry. The analysis period was 1999-2010. RESULTS: The Relative Risk for invasive, in situ, and total cancers diagnosed in participantwomen compared with non-participants were respectively 1.16 (0.94-1.43), 2.98 (1.16-7.62) and 1.22 (0.99-1.49). The Relative Risk for participants versus non-participants was 2.47 (1.55-3.96) for diagnosis at stagei, 2.58 (1.67-3.99) for T1 and 2.11 (1.38-3.23) for negative lymph node involvement. The cumulative incidence trend had two joint points in both arms, with an Annual Percent of Change of 92.3 (81.6-103.5) between 1999-2001, 18.2 (16.1-20.3) between 2001-2005 and 5.9 (4.0-7.8) for the last period in participants arm, and 72.6 (58.5-87.9) between 1999-2001, 12.6 (7.9-17.4) between 2001-2005, and 8.6 (6.5-10.6) in the last period in the non-participant arm. CONCLUSIONS: Participating in the breast cancer screening program analyzed increased the in situ cumulative cancer incidence, but not the invasive and total incidence. Diagnoses were earlier in the participant arm.
Authors: Juan Manuel Carmona-Torres; Ana Isabel Cobo-Cuenca; Noelia María Martín-Espinosa; Rosa María Piriz-Campos; José Alberto Laredo-Aguilera; María Aurora Rodríguez-Borrego Journal: Aten Primaria Date: 2017-07-19 Impact factor: 1.137