| Literature DB >> 25194807 |
Hui Fu1, Yan-Yan Tang2, Xin-Ping Ouyang2, Shi-Lin Tang1, Hua Su1, Xiaotao Li1, Li-Ping Huang1, Miao He1, Yun-Cheng Lv2, Ping-Ping He2, Feng Yao2, Yu-Lin Tan2, Wei Xie2, Min Zhang2, Jianfeng Wu3, Yuan Li2, Kong Chen3, Dan Liu2, Gang Lan2, Meng-Ya Zeng3, Xi-Long Zheng4, Chao-Ke Tang5.
Abstract
The purpose of this study is to determine whether IL-27 regulates macrophage ABCA1 expression, foam cell formation, and also explore the underlying mechanisms. Here, we revealed that IL-27 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux and increasing ABCA1 expression at both protein and mRNA levels. Our study further demonstrated that IL-27 increased ABCA1 level via activation of signal transducer and activator of transcription 3 (STAT3). Inhibition of Janus kinase 2, (JAK2)/STAT3 suppressed the stimulatory effects of IL-27 on ABCA1 expression. The present study concluded that IL-27 reduces lipid accumulation of foam cell by upregulating ABCA1 expression via JAK2/STAT3. Therefore, targeting IL-27 may offer a promising strategy to treat atherosclerotic vascular disease.Entities:
Keywords: ATP-binding cassette transporter A1; Foam cell; Interleukin-27; Janus kinase 2; Signal transducer and activator of transcription 3
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Year: 2014 PMID： 25194807 DOI： 10.1016/j.bbrc.2014.08.120
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575