| Literature DB >> 25194458 |
Irina D Alshakova1, Yuri V Ermolovich1, Vladimir N Zhabinskii1, Vladimir A Khripach2.
Abstract
A new route to the synthesis of minor brassinosteroids with a cholestane framework (28-norcastasterone and 28-norbrassinolide) has been proposed. It makes use of commercially available 24-epicastasterone as a starting material. In addition, [26,26,26-(2)H3]-28-norcastasterone and [26,26,26-(2)H3]-28-norbrassinolide have been prepared as tools for analytical applications. The key steps were regioselective manipulations of functional groups in 24-epicastasterone, oxidative cleavage of 22,23-diol group and Claisen rearrangement.Entities:
Keywords: 24-Epicastasterone; 28-Norbrassinolide; Boric acid ester; Brassinosteroids; Claisen rearrangement; Deuterated analogues
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Year: 2014 PMID： 25194458 DOI： 10.1016/j.steroids.2014.08.020
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668