Sébastien P J Krul1, Veronique M F Meijborg1, Wouter R Berger1, André C Linnenbank2, Antoine H G Driessen1, Wim-Jan van Boven1, Arthur A M Wilde1, Jacques M de Bakker2, Ruben Coronel3, Joris R de Groot4. 1. Heart Center, Department of Experimental Cardiology, Cardiology and Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2. Heart Center, Department of Experimental Cardiology, Cardiology and Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands. 3. Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands; L' Institut de RYthmnologie en modélisation Cardiaque (LIRYC), Université Bordeaux Segalen, Bordeaux, France. 4. Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands. Electronic address: j.r.degroot@amc.uva.nl.
Abstract
BACKGROUND: In patients with atrial fibrillation (AF), the autonomic nervous system is supposed to play an role in triggering AF; however, little is known of the effect on atrial conduction characteristics. OBJECTIVE: The purpose of this study was to study the effect of ganglionic plexus (GP) stimulation during sinus rhythm on atrial and pulmonary vein conduction in patients during thoracoscopic surgery for AF METHODS: In 25 patients, the anterior right ganglionic plexus (ARGP) was stimulated (16 Hz, at 1, 2, and 5 mA). Epicardial electrograms were recorded using a 48-electrode map from the right pulmonary vein (RPV) or right atrial (RA). Intra-atrial activation time (IAT), local activation time (LAT), and inhomogeneity of conduction (IIC) were determined. ECG parameters (P-P, P-R interval) were measured. RESULTS: P-P interval was 956 ± 157 ms (range 768-1368 ms), and P-R interval was 203 ± 37 ms (range 136-280 ms). After ARGP stimulation, a short-lasting increase of P-P interval was observed, more prominent at higher output (1 mA = 82 ms, 2 mA = 180 ms, 5 mA = 268 ms, all P <.01 vs baseline). P-R interval remained unchanged. IAT was 34.4 ms (range 5.6-50.3 ms) at the RA and 105.8 ms (range 79.7-163.3 ms) at the RPV. After 1-mA stimulation IAT increased, in patients taking beta-blockers (P = .001), or it decreased, and this change persisted after subsequent stimulation at higher current (1 mA, P = .001; 2 mA, P = .401; 5 mA, P = .593). Similar changes were observed for LAT and IIC. CONCLUSION: ARGP stimulation results in a short-lasting, output-dependent decrease in sinus node frequency due to a parasympathetic response. Stimulation of the ARGP induced a prolonged increase or decrease in conduction characteristics in patients with AF, consistent with a persistent differential parasympathetic and/or sympathetic response.
BACKGROUND: In patients with atrial fibrillation (AF), the autonomic nervous system is supposed to play an role in triggering AF; however, little is known of the effect on atrial conduction characteristics. OBJECTIVE: The purpose of this study was to study the effect of ganglionic plexus (GP) stimulation during sinus rhythm on atrial and pulmonary vein conduction in patients during thoracoscopic surgery for AF METHODS: In 25 patients, the anterior right ganglionic plexus (ARGP) was stimulated (16 Hz, at 1, 2, and 5 mA). Epicardial electrograms were recorded using a 48-electrode map from the right pulmonary vein (RPV) or right atrial (RA). Intra-atrial activation time (IAT), local activation time (LAT), and inhomogeneity of conduction (IIC) were determined. ECG parameters (P-P, P-R interval) were measured. RESULTS:P-P interval was 956 ± 157 ms (range 768-1368 ms), and P-R interval was 203 ± 37 ms (range 136-280 ms). After ARGP stimulation, a short-lasting increase of P-P interval was observed, more prominent at higher output (1 mA = 82 ms, 2 mA = 180 ms, 5 mA = 268 ms, all P <.01 vs baseline). P-R interval remained unchanged. IAT was 34.4 ms (range 5.6-50.3 ms) at the RA and 105.8 ms (range 79.7-163.3 ms) at the RPV. After 1-mA stimulation IAT increased, in patients taking beta-blockers (P = .001), or it decreased, and this change persisted after subsequent stimulation at higher current (1 mA, P = .001; 2 mA, P = .401; 5 mA, P = .593). Similar changes were observed for LAT and IIC. CONCLUSION: ARGP stimulation results in a short-lasting, output-dependent decrease in sinus node frequency due to a parasympathetic response. Stimulation of the ARGP induced a prolonged increase or decrease in conduction characteristics in patients with AF, consistent with a persistent differential parasympathetic and/or sympathetic response.
Authors: Jason D Bayer; Bastiaan J Boukens; Sébastien P J Krul; Caroline H Roney; Antoine H G Driessen; Wouter R Berger; Nicoline W E van den Berg; Arie O Verkerk; Edward J Vigmond; Ruben Coronel; Joris R de Groot Journal: Front Physiol Date: 2019-09-04 Impact factor: 4.566
Authors: Martin van Zyl; Mariam Khabsa; Jason A Tri; Thomas P Ladas; Omar Z Yasin; Adetola O Ladejobi; John Reilly; Barry O'Brien; Kenneth Coffey; Samuel J Asirvatham Journal: J Innov Card Rhythm Manag Date: 2022-07-15
Authors: Jolien Neefs; Shaëlle A Ons; Wouter R Berger; Sébastien P J Krul; Nicoline W E van den Berg; Femke R Piersma; Marcel A M Beijk; WimJan P van Boven; Antoine H G Driessen; Joris R de Groot Journal: J Interv Card Electrophysiol Date: 2020-03-14 Impact factor: 1.900