Yanira Franco-Murillo1, José Antonio Miranda-Rodríguez2, Erika Rendón-Huerta3, Luis F Montaño3, Gerardo Velázquez Cornejo4, Lucila Poblano Gómez4, Francisco Javier Valdez-Morales1, Ignacio Gonzalez-Sanchez1, Marco Cerbón5. 1. Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico, Federal District, Mexico. 2. Unidad de Endoscopia e Infertilidad, Hospital de la Mujer, Secretaria de Salud, Mexico, Mexico. 3. Departamento Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico, Federal District, Mexico. 4. Servicio de Ginecología y Obstetricia, Hospital Español, Mexico, Federal District, Mexico. 5. Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico, Federal District, Mexico mcerbon85@yahoo.com.mx.
Abstract
OBJECTIVE: Endometriosis is linked to altered cell proliferation and stem cell markers c-kit/stem cell factor (SCF) in ectopic endometrium. Our aim was to investigate whether c-kit/SCF also plays a role in eutopic endometrium. DESIGN: Eutopic endometrium obtained from 35 women with endometriosis and 25 fertile eumenorrheic women was analyzed for in situ expression of SCF/c-kit, Ki67, RAC-alpha serine/threonine-protein kinase (Akt), phosphorylated RAC-alpha serine/threonin-protein kinase (pAkt), Glycogen synthase kinase 3 beta (GSK3β), and phosphorylated glycogen synthase kinase 3 beta (pGSK3β), throughout the menstrual cycle. RESULTS: Expression of Ki67 and SCF was higher in endometriosis than in control tissue (P < .05) and greater in secretory rather than proliferative (P < .01) endometrium in endometriosis. Expression of c-kit was also higher in endometriosis although similar in both phases. Expression of Akt and GSK3β was identical in all samples and cycle phases, whereas pAkt and pGSK3β, opposed to control tissue, remained overexpressed in the secretory phase in endometriosis. CONCLUSION: Unceasing cell proliferation in the secretory phase of eutopic endometriosis is linked to deregulation of c-kit/SCF-associated signaling pathways.
OBJECTIVE:Endometriosis is linked to altered cell proliferation and stem cell markers c-kit/stem cell factor (SCF) in ectopic endometrium. Our aim was to investigate whether c-kit/SCF also plays a role in eutopic endometrium. DESIGN: Eutopic endometrium obtained from 35 women with endometriosis and 25 fertile eumenorrheicwomen was analyzed for in situ expression of SCF/c-kit, Ki67, RAC-alpha serine/threonine-protein kinase (Akt), phosphorylated RAC-alpha serine/threonin-protein kinase (pAkt), Glycogen synthase kinase 3 beta (GSK3β), and phosphorylated glycogen synthase kinase 3 beta (pGSK3β), throughout the menstrual cycle. RESULTS: Expression of Ki67 and SCF was higher in endometriosis than in control tissue (P < .05) and greater in secretory rather than proliferative (P < .01) endometrium in endometriosis. Expression of c-kit was also higher in endometriosis although similar in both phases. Expression of Akt and GSK3β was identical in all samples and cycle phases, whereas pAkt and pGSK3β, opposed to control tissue, remained overexpressed in the secretory phase in endometriosis. CONCLUSION: Unceasing cell proliferation in the secretory phase of eutopic endometriosis is linked to deregulation of c-kit/SCF-associated signaling pathways.
Authors: F R Oliveira; C Dela Cruz; H L Del Puerto; Q T M F Vilamil; F M Reis; A F Camargos Journal: Histol Histopathol Date: 2012-01 Impact factor: 2.303
Authors: C Adriana Mendoza-Rodríguez; Horacio Merchant-Larios; Maria L Segura-Valdez; Norma Moreno-Mendoza; María E Cruz; Paola Arteaga-López; Ignacio Camacho-Arroyo; Roberto Domínguez; Marco Cerbón Journal: Mol Reprod Dev Date: 2003-04 Impact factor: 2.609