Josep Franch-Nadal1, Pilar Roura-Olmeda2, Belén Benito-Badorrey3, Antonio Rodriguez-Poncelas4, Gabriel Coll-de-Tuero5, Manel Mata-Cases6. 1. Primary Care Center Raval Sud, Barcelona, Spain; Barcelona Ciutat Research Support Unit - IDIAP Jordi Gol, Barcelona, Spain; josep.franch@gmail.com. 2. PCC Badía del Vallés, Barcelona, Spain; 3. Primary Care Center Raval Sud, Barcelona, Spain; 4. PCC Anglés, Girona, Spain; Research Unit, Healthcare Institute, Girona, Spain; 5. PCC Anglés, Girona, Spain; Research Unit, Healthcare Institute, Girona, Spain; Translab. Departament of Medical Sciences, University of Girona, Girona, Spain and. 6. Barcelona Ciutat Research Support Unit - IDIAP Jordi Gol, Barcelona, Spain; PCC La Mina, Sant Adrià de Besòs, Barcelona, Spain.
Abstract
BACKGROUND: Control of glycaemic levels as well as cardiovascular risk factors (CVRF) is essential to prevent the onset of complications associated with type 2 diabetes mellitus (T2DM). AIM: To describe the degree of glycaemic control and CVRF in relation to diabetes duration. PATIENTS AND METHODS: Multicentre cross-sectional study in T2DM patients seen in primary care centres during 2007. VARIABLES: Demographical and clinical characteristics, antidiabetic treatments and development of disease complications. Diabetes duration classification: 0-5, 6-10, 11-20 and >20 years. Logistic regression models were used in the analysis. RESULTS: A total of 3130 patients; 51.5% males; mean age: 68±11.7 years; mean diabetes duration:7.0 (±5.6) years, median: 5 (interquartile range:3-9) years; mean HbA1c: 6.84 (±1.5), were analyzed. There has been a progressive decline in HbA1c levels (HbA1c > 7% in 25.8% of patients during the first 5 years and 51.8% after 20 years). Blood pressure values remained relatively stable throughout disease duration. The mean value of low density lipoprotein (LDL) experienced a slight decline with the progression of the disease, but due to the significant increase of cardiovascular disease (CVD) after 20 years of duration, less patients reached the recommended target (LDL < 100mg/dl) in secondary prevention. Logistic regression model controlling for age, sex and CVD showed that diabetes duration was related to glycaemic control (odds ratio: 1.066, 95% confidence interval: 1.050-1.082 per year) but not to blood pressure or LDL control. CONCLUSIONS: The degree of glycaemic control and the risk factors in relation to the duration of T2DM followed different patterns. Diabetes duration was associated with a poorer glycaemic control but in general had a limited role in blood pressure control or lipid profile.
BACKGROUND: Control of glycaemic levels as well as cardiovascular risk factors (CVRF) is essential to prevent the onset of complications associated with type 2 diabetes mellitus (T2DM). AIM: To describe the degree of glycaemic control and CVRF in relation to diabetes duration. PATIENTS AND METHODS: Multicentre cross-sectional study in T2DM patients seen in primary care centres during 2007. VARIABLES: Demographical and clinical characteristics, antidiabetic treatments and development of disease complications. Diabetes duration classification: 0-5, 6-10, 11-20 and >20 years. Logistic regression models were used in the analysis. RESULTS: A total of 3130 patients; 51.5% males; mean age: 68±11.7 years; mean diabetes duration:7.0 (±5.6) years, median: 5 (interquartile range:3-9) years; mean HbA1c: 6.84 (±1.5), were analyzed. There has been a progressive decline in HbA1c levels (HbA1c > 7% in 25.8% of patients during the first 5 years and 51.8% after 20 years). Blood pressure values remained relatively stable throughout disease duration. The mean value of low density lipoprotein (LDL) experienced a slight decline with the progression of the disease, but due to the significant increase of cardiovascular disease (CVD) after 20 years of duration, less patients reached the recommended target (LDL < 100mg/dl) in secondary prevention. Logistic regression model controlling for age, sex and CVD showed that diabetes duration was related to glycaemic control (odds ratio: 1.066, 95% confidence interval: 1.050-1.082 per year) but not to blood pressure or LDL control. CONCLUSIONS: The degree of glycaemic control and the risk factors in relation to the duration of T2DM followed different patterns. Diabetes duration was associated with a poorer glycaemic control but in general had a limited role in blood pressure control or lipid profile.
Authors: Jun Jie Benjamin Seng; Amelia Yuting Monteiro; Yu Heng Kwan; Sueziani Binte Zainudin; Chuen Seng Tan; Julian Thumboo; Lian Leng Low Journal: BMC Med Res Methodol Date: 2021-03-11 Impact factor: 4.615
Authors: Domingo Orozco-Beltrán; Cristóbal Morales; Sara Artola-Menéndez; Carlos Brotons; Sara Carrascosa; Cintia González; Óscar Baro; Alberto Aliaga; Karine Ferreira de Campos; María Villarejo; Carlos Hurtado; Carolina Álvarez-Ortega; Antón Gómez-García; Marta Cedenilla; Gonzalo Fernández Journal: JMIR Diabetes Date: 2022-10-03
Authors: J Cárdenas-Valladolid; A López-de Andrés; R Jiménez-García; M J de Dios-Duarte; P Gómez-Campelo; C de Burgos-Lunar; F J San Andrés-Rebollo; J C Abánades-Herranz; M A Salinero-Fort Journal: BMC Fam Pract Date: 2018-07-24 Impact factor: 2.497