Mehmet Erol Yildirim1, Akif Koc2, Ikbal Cekmen Kaygusuz3, Hüseyin Badem4, Omer Faruk Karatas5, Ersin Cimentepe5, Dogan Unal6. 1. Department of Urology, Turgut Ozal University, Faculty of Medicine, Ankara 06510, Turkey. doctorerol@yahoo.com. 2. Department of Urology, Balikesir University, Faculty of Medicine, Balikesir 10310, Turkey. 3. Department of Gynecology and Obstetrics, Turgut Ozal University Faculty of Mediine, Ankara 06510, Turkey. 4. Department of Urology, Yüksek Ihtisas Training and Research Hospital, Ankara 06520, Turkey. 5. Department of Urology, Turgut Ozal University, Faculty of Medicine, Ankara 06510, Turkey. 6. Department of Urology, Hacettepe University Faculty of Medicine, Ankara 06520, Turkey.
Abstract
PURPOSE: To evaluate the predictive power of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, testicular biopsy histology and male age were evaluated with respect to the success of sperm retrieval in a microdissection testicular sperm extraction (microTESE) procedure, pregnancy and live birth rates. MATERIALS AND METHODS: We examined the data of 131 infertile men with non-obstructive azoospermia, who have undergone microTESE operation. The men were classified into two groups based on serum follicle-stimulating hormone (FSH) levels ≤ 15 mIU/mL (group 1) and > 15 mIU/mL (group 2). RESULTS: Group 1 consisted of 59 patients (mean age 36.2 ± 6.2 years) and group 2 consisted of 72 (mean age 38.8 ± 7.4 years) patients. Sperm retrieval and pregnancy rates were 66.1% and 16.9% in normal FSH group, respectively. These parameters were higher than those of men with FSH > 15 (43% and 8.3%, respectively). Only 128 patients had histopathological diagnosis. Sperm was retrieved from 12/30 (40%) patients with maturation arrest, 9/29 (31.03%) patients with seminiferous tubules atrophy, 14/40 (35%) patients with sertoli cell only syndrome and 13/13 (100%) of patients with hypospermatogenesis. There was no statistically significant difference in pathological diagnosis between pregnancy and live birth rates. CONCLUSION: These results demonstrate that there is a significant difference with sperm retrieval, pregnancy rates and live birth rates comparing the FSH levels. Histopathological findings did not associate with successful microTESE, pregnancy rates and live birth rates.
PURPOSE: To evaluate the predictive power of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, testicular biopsy histology and male age were evaluated with respect to the success of sperm retrieval in a microdissection testicular sperm extraction (microTESE) procedure, pregnancy and live birth rates. MATERIALS AND METHODS: We examined the data of 131 infertile men with non-obstructive azoospermia, who have undergone microTESE operation. The men were classified into two groups based on serum follicle-stimulating hormone (FSH) levels ≤ 15 mIU/mL (group 1) and > 15 mIU/mL (group 2). RESULTS: Group 1 consisted of 59 patients (mean age 36.2 ± 6.2 years) and group 2 consisted of 72 (mean age 38.8 ± 7.4 years) patients. Sperm retrieval and pregnancy rates were 66.1% and 16.9% in normal FSH group, respectively. These parameters were higher than those of men with FSH > 15 (43% and 8.3%, respectively). Only 128 patients had histopathological diagnosis. Sperm was retrieved from 12/30 (40%) patients with maturation arrest, 9/29 (31.03%) patients with seminiferous tubules atrophy, 14/40 (35%) patients with sertoli cell only syndrome and 13/13 (100%) of patients with hypospermatogenesis. There was no statistically significant difference in pathological diagnosis between pregnancy and live birth rates. CONCLUSION: These results demonstrate that there is a significant difference with sperm retrieval, pregnancy rates and live birth rates comparing the FSH levels. Histopathological findings did not associate with successful microTESE, pregnancy rates and live birth rates.
Authors: Gianni Paulis; Luca Paulis; Gennaro Romano; Carmen Concas; Marika Di Sarno; Renata Pagano; Antonio Di Filippo; Maria Luisa Di Petrillo Journal: Res Rep Urol Date: 2017-10-30
Authors: Parviz K Kavoussi; Brady T West; Shu-Hung Chen; Caitlin Hunn; Melissa S Gilkey; G Luke Machen; Keikhosrow M Kavoussi; Amy Esqueda; J David Wininger; Shahryar K Kavoussi Journal: Reprod Biol Endocrinol Date: 2020-08-26 Impact factor: 5.211