Literature DB >> 25193962

Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.

Xin Jiang1, Honggang Guo1, Jianguo Wu1, Qiang He2, Yiqiao Li2, Miao Wang3, Hongyang Pan4, Wande Li5, Jinjie Wang1, Qingqing Wang6, Jing Shen1, Yuehai Ke1, Ren Zhou7.   

Abstract

Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc transcriptional activity, which results in the repression of proliferative phenotype signatures of germinal center lymphoma. Furthermore, SHP2/ERK signaling is required to maintain the CD19/c-Myc loop, which preferentially promotes survival of a distinct subtype of germinal center lymphoma cells carrying the MYC/IGH translocation. These findings demonstrate a critical function for SHP2/ERK signaling upstream of c-Myc in germinal center lymphoma cells and provide a rationale for targeting SHP2 in the therapy of germinal center lymphoma. Copyright© Ferrata Storti Foundation.

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Year:  2014        PMID： 25193962      PMCID： PMC4258751          DOI： 10.3324/haematol.2014.106401

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  50 in total

1.  Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

Authors:  R Sears; F Nuckolls; E Haura; Y Taya; K Tamai; J R Nevins
Journal:  Genes Dev       Date:  2000-10-01       Impact factor: 11.361

Review 2.  Lymphoid malignancies: the dark side of B-cell differentiation.

Authors:  A L Shaffer; Andreas Rosenwald; Louis M Staudt
Journal:  Nat Rev Immunol       Date:  2002-12       Impact factor: 53.106

3.  Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

Authors:  S L Nutt; P Urbánek; A Rolink; M Busslinger
Journal:  Genes Dev       Date:  1997-02-15       Impact factor: 11.361

Review 4.  Germinal centers: form and function.

Authors:  D Tarlinton
Journal:  Curr Opin Immunol       Date:  1998-06       Impact factor: 7.486

5.  Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.

Authors:  C K Qu; S Nguyen; J Chen; G S Feng
Journal:  Blood       Date:  2001-02-15       Impact factor: 22.113

6.  Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes.

Authors:  Y Miyakawa; P Rojnuckarin; T Habib; K Kaushansky
Journal:  J Biol Chem       Date:  2000-10-27       Impact factor: 5.157

7.  Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets.

Authors:  Alessandra De Leo; Giuseppe Arena; Egidio Lacanna; Giorgio Oliviero; Francesca Colavita; Elena Mattia
Journal:  Antiviral Res       Date:  2012-09-15       Impact factor: 5.970

Review 8.  The germinal center response.

Authors:  Kristy L Wolniak; Stephen M Shinall; Thomas J Waldschmidt
Journal:  Crit Rev Immunol       Date:  2004       Impact factor: 2.214

Review 9.  Protein-tyrosine phosphatases and cancer.

Authors:  Arne Ostman; Carina Hellberg; Frank D Böhmer
Journal:  Nat Rev Cancer       Date:  2006-04       Impact factor: 60.716

10.  Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.

Authors:  F M Uckun; W Jaszcz; J L Ambrus; A S Fauci; K Gajl-Peczalska; C W Song; M R Wick; D E Myers; K Waddick; J A Ledbetter
Journal:  Blood       Date:  1988-01       Impact factor: 22.113
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  2 in total

1.  Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma.

Authors:  Ning Ding; Xitao Li; Yunfei Shi; Lingyan Ping; Lina Wu; Kai Fu; Lixia Feng; Xiaohui Zheng; Yuqin Song; Zhengying Pan; Jun Zhu
Journal:  Oncotarget       Date:  2015-06-20

2.  Mutations driving CLL and their evolution in progression and relapse.

Authors:  Dan A Landau; Eugen Tausch; Amaro N Taylor-Weiner; Chip Stewart; Johannes G Reiter; Jasmin Bahlo; Sandra Kluth; Ivana Bozic; Mike Lawrence; Sebastian Böttcher; Scott L Carter; Kristian Cibulskis; Daniel Mertens; Carrie L Sougnez; Mara Rosenberg; Julian M Hess; Jennifer Edelmann; Sabrina Kless; Michael Kneba; Matthias Ritgen; Anna Fink; Kirsten Fischer; Stacey Gabriel; Eric S Lander; Martin A Nowak; Hartmut Döhner; Michael Hallek; Donna Neuberg; Gad Getz; Stephan Stilgenbauer; Catherine J Wu
Journal:  Nature       Date:  2015-10-14       Impact factor: 49.962
  2 in total

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