A Lefebvre1, C Fiet1, C Belpois-Duchamp1, M Tiv1, K Astruc1, L S Aho Glélé2. 1. Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France. 2. Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France. Electronic address: Ludwig.aho@chu-dijon.fr.
Abstract
OBJECTIVE: Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers. METHODS: We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species. RESULTS: Twenty outbreaks, including the current one, were studied. The estimated case fatality rate was 65.4% (CI 95% [54.6%; 75.5%]) and varied among the outbreaks. A species effect was identified, with a higher case fatality rate for the Zaire species than for Sudan and Bundibugyo species. The case fatality rate of the Zaire species tended to decrease with time. CONCLUSION: The case fatality rates associated with these 3 species was high. A great variability was observed. It could be explained partly by a species effect and by the decrease of Zaire species case fatality rate, with time.
OBJECTIVE: Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers. METHODS: We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species. RESULTS: Twenty outbreaks, including the current one, were studied. The estimated case fatality rate was 65.4% (CI 95% [54.6%; 75.5%]) and varied among the outbreaks. A species effect was identified, with a higher case fatality rate for the Zaire species than for Sudan and Bundibugyo species. The case fatality rate of the Zaire species tended to decrease with time. CONCLUSION: The case fatality rates associated with these 3 species was high. A great variability was observed. It could be explained partly by a species effect and by the decrease of Zaire species case fatality rate, with time.
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