Literature DB >> 25193067

Inhaled antimicrobial therapy - barriers to effective treatment.

Jeffry Weers1.   

Abstract

Inhaled antibiotics dramatically improve targeting of drug to the site of respiratory infections, while simultaneously minimizing systemic exposure and associated toxicity. The high local concentrations of antibiotic may enable more effective treatment of multi-drug resistant pathogens. This review explores barriers to effective treatment with inhaled antibiotics. In addition, potential opportunities for improvements in treatment are reviewed.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Biofilm; Dry powder inhaler; Endpoint; Fixed dose combination; Nebulizer; Partial liquid ventilation; Tolerability

Mesh：

Substances：

Year:  2014        PMID： 25193067     DOI： 10.1016/j.addr.2014.08.013

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  21 in total

1.  Aerosol delivery into small anatomical airway model through spontaneous engineered breathing.

Authors:  Chun-Kai Lin; Yuan-Yuan Hsiao; Pulak Nath; Jen-Huang Huang
Journal:  Biomicrofluidics       Date:  2019-08-07       Impact factor: 2.800

2.  Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children.

Authors:  Dale Farkas; Michael Hindle; Serena Bonasera; Karl Bass; Worth Longest
Journal:  J Aerosol Med Pulm Drug Deliv       Date:  2019-08-29       Impact factor: 2.849

3.  A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics.

Authors:  David L Hava; Lisa Tan; Patrick Johnson; Aidan K Curran; Jason Perry; Steve Kramer; Katie Kane; Pauline Bedwell; Gary Layton; Clarie Swann; Dennis Henderson; Naimat Khan; Lucy Connor; Litza McKenzie; Dave Singh; James Roach
Journal:  Br J Clin Pharmacol       Date:  2020-01-16       Impact factor: 4.335

Review 4.  Use of computational fluid dynamics deposition modeling in respiratory drug delivery.

Authors:  P Worth Longest; Karl Bass; Rabijit Dutta; Vijaya Rani; Morgan L Thomas; Ahmad El-Achwah; Michael Hindle
Journal:  Expert Opin Drug Deliv       Date:  2018-12-10       Impact factor: 6.648

5.  Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections.

Authors:  Sharad Mangal; Jiayang Huang; Nivedita Shetty; Heejun Park; Yu-Wei Lin; Heidi H Yu; Dmitry Zemlyanov; Tony Velkov; Jian Li; Qi Tony Zhou
Journal:  Int J Pharm       Date:  2019-02-21       Impact factor: 5.875

6.  Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a Spray-Dried Antibiotic Formulation and Pediatric Air-Jet DPI.

Authors:  Dale Farkas; Morgan L Thomas; Amr Hassan; Serena Bonasera; Michael Hindle; Worth Longest
Journal:  Pharm Res       Date:  2022-06-27       Impact factor: 4.200

7.  Micro-fluidic Spray Freeze Dried Ciprofloxacin Hydrochloride-Embedded Dry Powder for Inhalation.

Authors:  Yingjie Chen; Shen Yan; Shengyu Zhang; Quanyi Yin; Xiao Dong Chen; Winston Duo Wu
Journal:  AAPS PharmSciTech       Date:  2022-08-02       Impact factor: 4.026

8.  Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation.

Authors:  Sharad Mangal; Haichen Nie; Rongkun Xu; Rui Guo; Alex Cavallaro; Dmitry Zemlyanov; Qi Tony Zhou
Journal:  Pharm Res       Date:  2018-01-08       Impact factor: 4.200

9.  Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation.

Authors:  Sharad Mangal; Heejun Park; Lingfei Zeng; Heidi H Yu; Yu-Wei Lin; Tony Velkov; John A Denman; Dmitry Zemlyanov; Jian Li; Qi Tony Zhou
Journal:  Int J Pharm       Date:  2018-07-03       Impact factor: 5.875

10.  How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder?

Authors:  Qi Tony Zhou; Zhi Hui Loh; Jiaqi Yu; Si-Ping Sun; Thomas Gengenbach; John A Denman; Jian Li; Hak-Kim Chan
Journal:  AAPS J       Date:  2016-06-02       Impact factor: 4.009
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