| Literature DB >> 25192911 |
Seka S Lazare1, Edyta E Wojtowicz2, Leonid V Bystrykh2, Gerald de Haan2.
Abstract
miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation.Entities:
Keywords: Hematopoiesis; Lineage commitment; Transcription factors; microRNA
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Year: 2014 PMID: 25192911 DOI: 10.1016/j.yexcr.2014.08.033
Source DB: PubMed Journal: Exp Cell Res ISSN: 0014-4827 Impact factor: 3.905