Tae Hyung Kim1, Jin Woo Choi2, Hong Gee Roh1, Won-Jin Moon1, Sung Gyu Moon1, Young Il Chun3, Hahn Young Kim4. 1. Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea. 2. Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea. Electronic address: cardijin@gmail.com. 3. Department of Neurosurgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea. 4. Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea.
Abstract
OBJECTIVE: Prior to detecting intracranial arterial stenosis, atherosclerotic wall change or plaque with positive remodeling can be evaluated with high-resolution MRI (HRMRI). We prospectively evaluate atherosclerotic arterial wall change in patients without intracranial stenosis using HRMRI at 3.0T and correlate the atherosclerotic change, cerebrovascular risk factors, and white matter hyperintensity (WMH). METHODS: Patients were prospectively recruited for one year and underwent brain MRI, TOF-MRA and HRMRI using axial 3D T1 FSE of the intracranial arteries. After excluding patients with intracranial stenosis, two neuroradiologists graded the atherosclerotic change of the intracranial arterial wall on HRMRI and WMH using a 4-point scale. The relationship between atherosclerotic changes on HRMRI, cerebrovascular risk factors, and WMH were statistically evaluated. RESULTS: Eighty-three patients without intracranial arterial stenosis were finally included. Older age (p=0.000), hypertension (p=0.002), and hyperlipidemia (p=0.007) were associated with severe atherosclerotic change on HRMRI. On multivariate analysis, older age (OR: 0.114; 95% CI: 0.033-0.397; p=0.001) and hypertension (OR: 0.178; 95% CI: 0.049-0.651; p=0.009) were significantly associated with severe atherosclerotic change on HRMRI. The presence of moderate and severe WMH was associated with older age, hypertension, and severe atherosclerotic change on HRMRI. On multivariate analysis, atherosclerotic change on HRMRI remained the only variable significantly associated with WMH (OR: 0.086; 95% CI: 0.016-0461; p=0.004). CONCLUSION: Older age and hypertension are significantly associated with intracranial atherosclerotic change on HRMRI. Atherosclerotic change detected on HRMRI may be the strongest risk factor for WMH than any other cerebrovascular risk factor in patients without intracranial stenosis.
OBJECTIVE: Prior to detecting intracranial arterial stenosis, atherosclerotic wall change or plaque with positive remodeling can be evaluated with high-resolution MRI (HRMRI). We prospectively evaluate atherosclerotic arterial wall change in patients without intracranial stenosis using HRMRI at 3.0T and correlate the atherosclerotic change, cerebrovascular risk factors, and white matter hyperintensity (WMH). METHODS:Patients were prospectively recruited for one year and underwent brain MRI, TOF-MRA and HRMRI using axial 3D T1 FSE of the intracranial arteries. After excluding patients with intracranial stenosis, two neuroradiologists graded the atherosclerotic change of the intracranial arterial wall on HRMRI and WMH using a 4-point scale. The relationship between atherosclerotic changes on HRMRI, cerebrovascular risk factors, and WMH were statistically evaluated. RESULTS: Eighty-three patients without intracranial arterial stenosis were finally included. Older age (p=0.000), hypertension (p=0.002), and hyperlipidemia (p=0.007) were associated with severe atherosclerotic change on HRMRI. On multivariate analysis, older age (OR: 0.114; 95% CI: 0.033-0.397; p=0.001) and hypertension (OR: 0.178; 95% CI: 0.049-0.651; p=0.009) were significantly associated with severe atherosclerotic change on HRMRI. The presence of moderate and severe WMH was associated with older age, hypertension, and severe atherosclerotic change on HRMRI. On multivariate analysis, atherosclerotic change on HRMRI remained the only variable significantly associated with WMH (OR: 0.086; 95% CI: 0.016-0461; p=0.004). CONCLUSION: Older age and hypertension are significantly associated with intracranial atherosclerotic change on HRMRI. Atherosclerotic change detected on HRMRI may be the strongest risk factor for WMH than any other cerebrovascular risk factor in patients without intracranial stenosis.
Authors: Jae W Song; Brianna F Moon; Morgan P Burke; Srikant Kamesh Iyer; Mark A Elliott; Haochang Shou; Steven R Messé; Scott E Kasner; Laurie A Loevner; Mitchell D Schnall; John E Kirsch; Walter R Witschey; Zhaoyang Fan Journal: J Neuroimaging Date: 2020-05-11 Impact factor: 2.486
Authors: Mahmud Mossa-Basha; Hiroko Watase; Jie Sun; Dean K Shibata; Daniel S Hippe; Niranjan Balu; Thomas Hatsukami; Chun Yuan Journal: Br J Radiol Date: 2019-02-26 Impact factor: 3.039