Ilse Lamers1, Davide Cattaneo2, Christine C Chen3, Rita Bertoni4, Bart Van Wijmeersch5, Peter Feys6. 1. I. Lamers, PhD, REVAL-Rehabilitation Research Center, BIOMED-Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan Building A, 3590 Diepenbeek, Belgium. ilse.lamers@uhasselt.be. 2. D. Cattaneo, PhD, Larice Lab, Don Carlo Gnocchi Foundation, Milan, Italy. 3. C.C. Chen, ScD, OTR/L, Department of Rehabilitation Sciences, University of Texas-El Paso, El Paso, Texas. 4. R. Bertoni, MSc, Larice Lab, Don Carlo Gnocchi Foundation. 5. B. Van Wijmeersch, MD, PhD, REVAL-Rehabilitation Research Center, BIOMED-Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, and Rehabilitation and MS Center, Overpelt, Belgium. 6. P. Feys, PhD, REVAL-Rehabilitation Research Center, BIOMED-Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University.
Abstract
BACKGROUND: It is unknown how impairments caused by multiple sclerosis (MS) affect upper limb capacity, performance, and community integration. OBJECTIVE: The aim of this study was to investigate the extent to which impairments explained the variance in activity level and participation level measures of the International Classification of Functioning, Disability and Health (ICF) and the extent to which upper limb capacity measures explained perceived performance on the activity level in people with MS and different dexterity levels. DESIGN: This was a cross-sectional study. METHODS: A total of 105 people with MS (median Expanded Disability Status Scale=6.5) were assessed with measures on the ICF body functions and structures level (strength, active range of motion of the wrist, tactile sensitivity, tremor, spasticity, and pain), activity level (Nine-Hole Peg Test [NHPT], Action Research Arm Test, and Manual Ability Measure-36 [MAM-36]), and participation level (Community Integration Questionnaire). The sample was divided into low- and high-dexterity subgroups on the basis of the median score on the NHPT. RESULTS: In the total group, muscle strength, tactile sensitivity of the thumb, and intention tremor explained 53% to 64% of the variance in activity level measures. In the low-dexterity subgroup, muscle strength and active range of motion explained 43% to 71% of the variance in activity level measures. In the high-dexterity subgroup, only 35% of the variance in the MAM-36 was explained by muscle strength. Capacity measures (NHPT and Action Research Arm Test) were moderately to highly associated with perceived performance (MAM-36) in the low-dexterity subgroup. LIMITATIONS: Some outcome measures showed ceiling effects in people with MS and a high dexterity level. CONCLUSIONS: Upper limb muscle strength is the most important impairment affecting capacity and perceived performance in daily life. Associations among outcome measures differ in people with MS and different dexterity levels.
BACKGROUND: It is unknown how impairments caused by multiple sclerosis (MS) affect upper limb capacity, performance, and community integration. OBJECTIVE: The aim of this study was to investigate the extent to which impairments explained the variance in activity level and participation level measures of the International Classification of Functioning, Disability and Health (ICF) and the extent to which upper limb capacity measures explained perceived performance on the activity level in people with MS and different dexterity levels. DESIGN: This was a cross-sectional study. METHODS: A total of 105 people with MS (median Expanded Disability Status Scale=6.5) were assessed with measures on the ICF body functions and structures level (strength, active range of motion of the wrist, tactile sensitivity, tremor, spasticity, and pain), activity level (Nine-Hole Peg Test [NHPT], Action Research Arm Test, and Manual Ability Measure-36 [MAM-36]), and participation level (Community Integration Questionnaire). The sample was divided into low- and high-dexterity subgroups on the basis of the median score on the NHPT. RESULTS: In the total group, muscle strength, tactile sensitivity of the thumb, and intention tremor explained 53% to 64% of the variance in activity level measures. In the low-dexterity subgroup, muscle strength and active range of motion explained 43% to 71% of the variance in activity level measures. In the high-dexterity subgroup, only 35% of the variance in the MAM-36 was explained by muscle strength. Capacity measures (NHPT and Action Research Arm Test) were moderately to highly associated with perceived performance (MAM-36) in the low-dexterity subgroup. LIMITATIONS: Some outcome measures showed ceiling effects in people with MS and a high dexterity level. CONCLUSIONS: Upper limb muscle strength is the most important impairment affecting capacity and perceived performance in daily life. Associations among outcome measures differ in people with MS and different dexterity levels.
Authors: Ricardo N Alonso; Maria B Eizaguirre; Leila Cohen; Cecilia Quarracino; Berenice Silva; Maria C Pita; Cecilia Yastremiz; Sandra Vanotti; Orlando Garcea Journal: Int J MS Care Date: 2020-05-15
Authors: Peter Feys; Ilse Lamers; Gordon Francis; Ralph Benedict; Glenn Phillips; Nicholas LaRocca; Lynn D Hudson; Richard Rudick Journal: Mult Scler Date: 2017-02-16 Impact factor: 6.312
Authors: Sophie Cleanthous; Sara Strzok; Farrah Pompilus; Stefan Cano; Patrick Marquis; Stanley Cohan; Myla D Goldman; Kiren Kresa-Reahl; Jennifer Petrillo; Carmen Castrillo-Viguera; Diego Cadavid; Shih-Yin Chen Journal: Mult Scler J Exp Transl Clin Date: 2018-05-17
Authors: Caspar Ep van Munster; Marcus D'Souza; Saskia Steinheimer; Christian P Kamm; Jessica Burggraaff; Manuela Diederich; Kristina Kravalis; Jonas Dorn; Lorcan Walsh; Frank Dahlke; Ludwig Kappos; Bernard Mj Uitdehaag Journal: Mult Scler Date: 2018-08-31 Impact factor: 6.312