Yolanda Córdova-Galaviz1, Edgar Ledesma-Martínez1, Itzen Aguíñiga-Sánchez1, Gloria Soldevila-Melgarejo2, Isabel Soto-Cruz3, Benny Weiss-Steider1, Edelmiro Santiago-Osorio4. 1. Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico. 2. Department of Immunology, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico. 3. Oncology Laboratory, Research Unit on Cell Differentiation and Cancer, FES-Zaragoza, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico. 4. Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico edelmiro@unam.mx.
Abstract
BACKGROUND: Acute myeloid leukaemia is a neoplastic disease of haematopoietic stem cells. Although there have been recent advances regarding its treatment, mortality remains high. Consequently, therapeutic alternatives continue to be explored. In the present report, we present evidence that sodium caseinate (CasNa), a salt of the principal protein in milk, may possess important anti-leukaemic properties. MATERIALS AND METHODS: J774 leukaemia macrophage-like cells were cultured with CasNa and proliferation, viability and differentiation were evaluated. These cells were also inoculated into BALB/c mice as a model of leukemia. RESULTS: We demonstrated that CasNa inhibits the in vitro proliferation and reduces viability of J774 cells, and leads to increased survival in vivo in a leukaemic mouse model. CONCLUSION: These data indicate that CasNa may be useful in leukaemia therapy.
BACKGROUND: Acute myeloid leukaemia is a neoplastic disease of haematopoietic stem cells. Although there have been recent advances regarding its treatment, mortality remains high. Consequently, therapeutic alternatives continue to be explored. In the present report, we present evidence that sodium caseinate (CasNa), a salt of the principal protein in milk, may possess important anti-leukaemic properties. MATERIALS AND METHODS: J774 leukaemia macrophage-like cells were cultured with CasNa and proliferation, viability and differentiation were evaluated. These cells were also inoculated into BALB/c mice as a model of leukemia. RESULTS: We demonstrated that CasNa inhibits the in vitro proliferation and reduces viability of J774 cells, and leads to increased survival in vivo in a leukaemic mouse model. CONCLUSION: These data indicate that CasNa may be useful in leukaemia therapy.