Literature DB >> 25189825

Outcomes in adult life among siblings of individuals with autism.

Patricia Howlin1, Philippa Moss, Sarah Savage, Patrick Bolton, Michael Rutter.   

Abstract

Little is known about adult siblings of individuals with autism. We report on cognitive, social and mental health outcomes in 87 adult siblings (mean age 39 years). When younger all had been assessed either as being "unaffected" by autism (n = 69) or as meeting criteria for the "Broader Autism Phenotype" (BAP, n = 18). As adults, all scored within the average range on tests of intelligence, numeracy and literacy. "Unaffected" siblings were functioning well in terms of jobs, independence and social relationships. Levels of social relationships and employment were significantly lower in the BAP group; autism traits and mental health problems were significantly higher. The data suggest that the "broader autism phenotype" is a meaningful concept but more sensitive diagnostic measures are required.

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Year:  2015        PMID： 25189825     DOI： 10.1007/s10803-014-2224-5

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  31 in total

1.  Defining key features of the broad autism phenotype: a comparison across parents of multiple- and single-incidence autism families.

Authors:  Molly Losh; Debra Childress; Kristen Lam; Joseph Piven
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-06-05       Impact factor: 3.568

2.  An inventory for measuring clinical anxiety: psychometric properties.

Authors:  A T Beck; N Epstein; G Brown; R A Steer
Journal:  J Consult Clin Psychol       Date:  1988-12

3.  The broad autism phenotype questionnaire.

Authors:  Robert S E Hurley; Molly Losh; Morgan Parlier; J Steven Reznick; Joseph Piven
Journal:  J Autism Dev Disord       Date:  2006-12-05

4.  Recurrence of autism spectrum disorders in full- and half-siblings and trends over time: a population-based cohort study.

Authors:  Therese K Grønborg; Diana E Schendel; Erik T Parner
Journal:  JAMA Pediatr       Date:  2013-10       Impact factor: 16.193

5.  Sibling recurrence and the genetic epidemiology of autism.

Authors:  John N Constantino; Yi Zhang; Thomas Frazier; Anna M Abbacchi; Paul Law
Journal:  Am J Psychiatry       Date:  2010-10-01       Impact factor: 18.112

6.  Screening for obsessive and compulsive symptoms: validation of the Clark-Beck Obsessive-Compulsive Inventory.

Authors:  David A Clark; Martin M Antony; Aaron T Beck; Richard P Swinson; Robert A Steer
Journal:  Psychol Assess       Date:  2005-06

7.  De novo mutations revealed by whole-exome sequencing are strongly associated with autism.

Authors:  Stephan J Sanders; Michael T Murtha; Abha R Gupta; John D Murdoch; Melanie J Raubeson; A Jeremy Willsey; A Gulhan Ercan-Sencicek; Nicholas M DiLullo; Neelroop N Parikshak; Jason L Stein; Michael F Walker; Gordon T Ober; Nicole A Teran; Youeun Song; Paul El-Fishawy; Ryan C Murtha; Murim Choi; John D Overton; Robert D Bjornson; Nicholas J Carriero; Kyle A Meyer; Kaya Bilguvar; Shrikant M Mane; Nenad Sestan; Richard P Lifton; Murat Günel; Kathryn Roeder; Daniel H Geschwind; Bernie Devlin; Matthew W State
Journal:  Nature       Date:  2012-04-04       Impact factor: 49.962

8.  Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale.

Authors:  Geraldine Dawson; Annette Estes; Jeffrey Munson; Gerard Schellenberg; Raphael Bernier; Robert Abbott
Journal:  J Autism Dev Disord       Date:  2007-03

9.  The broader autism phenotype in simplex and multiplex families.

Authors:  Jennifer A Gerdts; Raphael Bernier; Geraldine Dawson; Annette Estes
Journal:  J Autism Dev Disord       Date:  2013-07

10.  The well-being of siblings of individuals with autism.

Authors:  Laura Green
Journal:  ISRN Neurol       Date:  2013-04-30
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  11 in total

1.  Electrophysiological Endophenotypes and the Error-Related Negativity (ERN) in Autism Spectrum Disorder: A Family Study.

Authors:  Ann Clawson; Mikle South; Scott A Baldwin; Michael J Larson
Journal:  J Autism Dev Disord       Date:  2017-05

2.  Subjective Poverty Moderates the Association Between Carer Status and Psychological Outcomes of Adult Siblings of People with Intellectual and Developmental Disabilities.

Authors:  Nikita K Hayden; Richard P Hastings; Clare Kassa; Frances Danylec
Journal:  J Autism Dev Disord       Date:  2022-03-19

3.  Future Directions for Infant Identification and Intervention for Autism Spectrum Disorder from a Transdiagnostic Perspective.

Authors:  Meagan R Talbott; Meghan R Miller
Journal:  J Clin Child Adolesc Psychol       Date:  2020-07-23

4.  Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment.

Authors:  Devon N Gangi; Monique Moore Hill; Shyeena Maqbool; Gregory S Young; Sally Ozonoff
Journal:  Autism Res       Date:  2021-05-19       Impact factor: 4.633

Review 5.  Siblings of Children with Autism: the Siblings Embedded Systems Framework.

Authors:  Hanna Kovshoff; Katie Cebula; Hsiao-Wei Joy Tsai; Richard P Hastings
Journal:  Curr Dev Disord Rep       Date:  2017-05-18

6.  A Population-Based Study of the Behavioral and Emotional Adjustment of Older Siblings of Children with and without Intellectual Disability.

Authors:  Nikita K Hayden; Richard P Hastings; Vasiliki Totsika; Emma Langley
Journal:  J Abnorm Child Psychol       Date:  2019-08

7.  Early Screening and Risk Factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients With Prader-Willi Syndrome.

Authors:  Xuejun Kong; Junli Zhu; Ruiyi Tian; Siyu Liu; Hannah T Sherman; Xiaoying Zhang; Xiaojing Lin; Yan Han; Zhi Xiang; Madelyn Koh; Clara Hobbie; Bryan Wang; Kevin Liu; Jun Liu; Yueping Yin; Guobin Wan
Journal:  Front Psychiatry       Date:  2020-11-26       Impact factor: 4.157

8.  The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder.

Authors:  Meghan Miller; Ana-Maria Iosif; Gregory S Young; Laura J Bell; A J Schwichtenberg; Ted Hutman; Sally Ozonoff
Journal:  J Child Psychol Psychiatry       Date:  2018-12-01       Impact factor: 8.982

9.  School-age outcomes of infants at risk for autism spectrum disorder.

Authors:  Meghan Miller; Ana-Maria Iosif; Gregory S Young; Monique Hill; Elise Phelps Hanzel; Ted Hutman; Scott Johnson; Sally Ozonoff
Journal:  Autism Res       Date:  2015-10-09       Impact factor: 5.216

10.  Language delay aggregates in toddler siblings of children with autism spectrum disorder.

Authors:  N Marrus; L P Hall; S J Paterson; J T Elison; J J Wolff; M R Swanson; J Parish-Morris; A T Eggebrecht; J R Pruett; H C Hazlett; L Zwaigenbaum; S Dager; A M Estes; R T Schultz; K N Botteron; J Piven; J N Constantino
Journal:  J Neurodev Disord       Date:  2018-10-22       Impact factor: 4.025
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