Literature DB >> 25189779

Gene regulatory networks by transcription factors and microRNAs in breast cancer.

Sheng Qin1, Fei Ma2, Liming Chen2.   

Abstract

MOTIVATION: Gene regulatory networks (GRNs) affect numerous cellular processes and every process of life, and abnormalities of GRN lead to breast cancer. Transcription factors (TFs) and microRNAs (miRNAs) are two of the best-studied gene regulatory mechanisms. However, the architecture and feature of GRNs by TFs and miRNAs in breast cancer and its subtypes were unknown. In this study, we investigated the GRNs by TFs and miRNAs with emphasis on breast cancer classifier genes at system level.
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Year:  2014        PMID： 25189779     DOI： 10.1093/bioinformatics/btu597

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  18 in total

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