H Del Castillo-Barrientos1, G Centeno-Luque1, A Untiveros-Tello1, B Simms2, L Lecca3, A K Nelson4, C Lastimoso5, S Shin3. 1. Servicio de Neumología, Instituto Nacional de Salud del Niño, Lima, Peru. 2. University of Washington School of Medicine, Seattle, Washington, USA. 3. Socios En Salud, Sucursal Peru, Lima, Peru. 4. Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA. 5. Boston Health Care for the Homeless, Somerville, Massachusetts, USA.
Abstract
OBJECTIVE: To describe clinical presentation across age groups in 2855 children with pulmonary tuberculosis (TB) attending the Children's Hospital, Lima, Peru, to improve the diagnosis, treatment and care of childhood TB. DESIGN: Children aged 0-14 years admitted between 1 January 1973 and 31 December 1997 with active pulmonary TB were enrolled. Demographic information, history, physical examination data, laboratory and microbiological results, chest radiograph data, disease classification, treatment and adverse effect data, and outcome at the time of discharge were recorded by pulmonologists using detailed chart abstractions. RESULTS: Of the 2855 enrollees, 47% were malnourished and 56% had a household contact. Older children presented with classic TB symptoms, while weight loss and anorexia were rare in children aged <5 years. Microbiological or pathologic confirmation was obtained in 71% of children aged 10-14 years compared with 34% of children aged <2 years; however, severe extra-pulmonary TB was most common among children aged <2 years (41%). CONCLUSION: Classic TB symptoms should be considered when making a diagnosis; however, systematic symptoms among young children are also important. In high-burden settings, clinicians should have a low threshold to diagnose and treat children for TB across all ages, even in the context of a negative tuberculin skin test result and lack of micro-pathological confirmation.
OBJECTIVE: To describe clinical presentation across age groups in 2855 children with pulmonary tuberculosis (TB) attending the Children's Hospital, Lima, Peru, to improve the diagnosis, treatment and care of childhood TB. DESIGN:Children aged 0-14 years admitted between 1 January 1973 and 31 December 1997 with active pulmonary TB were enrolled. Demographic information, history, physical examination data, laboratory and microbiological results, chest radiograph data, disease classification, treatment and adverse effect data, and outcome at the time of discharge were recorded by pulmonologists using detailed chart abstractions. RESULTS: Of the 2855 enrollees, 47% were malnourished and 56% had a household contact. Older children presented with classic TB symptoms, while weight loss and anorexia were rare in children aged <5 years. Microbiological or pathologic confirmation was obtained in 71% of children aged 10-14 years compared with 34% of children aged <2 years; however, severe extra-pulmonary TB was most common among children aged <2 years (41%). CONCLUSION: Classic TB symptoms should be considered when making a diagnosis; however, systematic symptoms among young children are also important. In high-burden settings, clinicians should have a low threshold to diagnose and treat children for TB across all ages, even in the context of a negative tuberculin skin test result and lack of micro-pathological confirmation.
Authors: Meredith B Brooks; Melanie M Dubois; Amyn A Malik; Junaid F Ahmed; Sara Siddiqui; Salman Khan; Manzoor Brohi; Teerath Das Valecha; Farhana Amanullah; Mercedes C Becerra; Hamidah Hussain Journal: PLoS One Date: 2022-02-18 Impact factor: 3.240