Literature DB >> 2518808

AP1, a composite transcription factor implicated in abnormal growth control.

J L Imler1, B Wasylyk.   

Abstract

Growth factors activate cascades of intracellular events, some of which result in altered gene expression. A series of recent discoveries have highlighted the role of the transcription factor AP1 as a mediator of the effects of growth factors, as well as those of oncogenes and the tumour promoter TPA. We discuss the molecular composition of AP1, how its activity is thought to be regulated, and the evidence that AP1 activation is involved in transformation.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2518808     DOI： 10.1016/0955-2235(89)90001-x

Source DB:  PubMed          Journal:  Prog Growth Factor Res        ISSN： 0955-2235


  10 in total

1.  Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor.

Authors:  A Weisz; R Rosales
Journal:  Nucleic Acids Res       Date:  1990-09-11       Impact factor: 16.971

2.  Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors.

Authors:  Amani Batarseh; Jiehan Li; Vassilios Papadopoulos
Journal:  Biochemistry       Date:  2010-06-15       Impact factor: 3.162

3.  Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways.

Authors:  Suboj Babykutty; Priya Suboj; Priya Srinivas; Asha S Nair; K Chandramohan; Srinivas Gopala
Journal:  Clin Exp Metastasis       Date:  2012-03-15       Impact factor: 5.150

4.  Activation of junB by PKC and PKA signal transduction through a novel cis-acting element.

Authors:  R P de Groot; J Auwerx; M Karperien; B Staels; W Kruijer
Journal:  Nucleic Acids Res       Date:  1991-02-25       Impact factor: 16.971

5.  EGF-induced jun B-expression in transfected P19 embryonal carcinoma cells expressing EGF-receptors is dependent on Jun D.

Authors:  J den Hertog; R P de Groot; S W de Laat; W Kruijer
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

6.  Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.

Authors:  Manesh Chittezhath; Gagan Deep; Rana P Singh; Chapla Agarwal; Rajesh Agarwal
Journal:  Mol Cancer Ther       Date:  2008-07       Impact factor: 6.261

7.  Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells.

Authors:  Mallikarjuna Gu; Komal Raina; Chapla Agarwal; Rajesh Agarwal
Journal:  Mol Carcinog       Date:  2010-01       Impact factor: 4.784

8.  The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

Authors:  A Gutman; B Wasylyk
Journal:  EMBO J       Date:  1990-07       Impact factor: 11.598

Review 9.  Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II).

Authors:  Fuzhou Wang; George B Stefano; Richard M Kream
Journal:  Med Sci Monit       Date:  2014-07-12

10.  PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes.

Authors:  C Wasylyk; P Flores; A Gutman; B Wasylyk
Journal:  EMBO J       Date:  1989-11       Impact factor: 11.598
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.