Letter to the editor: investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model.

The article entitled "Investigation of Efficacy of Mitomycin-C, Sodium Hyaluronate and Human Amniotic Fluid in Preventing Epidural Fibrosis and Adhesion Using a Rat Laminectomy Model" published in the Asian Spine Journal highlights an important problem for spinal surgeons [1]. We are thankful to the authors for their comments and informative letter, which highlights the doses which might be helpful in further research. The authors are right because using different dissolving methods can affect the results, but we didn't add any dissolving solution. Regarding the second point about dosage and density, we used a 0.01% mitomycin C solution [2] (an instant preparation that is usually used for ophthalmologic disorders) and 0.1 mL sodium hyaluronate [3]. Referring to the last question about the duration time, all of the drugs were applied 3 minutes. We hope those information are helpful and may encourage further research.