Belinda M Brown1, Pierrick Bourgeat1, Jeremiah J Peiffer1, Samantha Burnham1, Simon M Laws1, Stephanie R Rainey-Smith1, David Bartrés-Faz1, Victor L Villemagne1, Kevin Taddei1, Alan Rembach1, Ashley Bush1, Kathryn A Ellis1, S Lance Macaulay1, Christopher C Rowe1, David Ames1, Colin L Masters1, Paul Maruff1, Ralph N Martins2. 1. From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. 2. From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. ralph.n.martins@gmail.com.
Abstract
OBJECTIVE: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. METHODS: This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations. RESULTS: The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = -0.22, p = 0.02) and temporal lobe (β = -0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume. CONCLUSION: The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.
OBJECTIVE: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. METHODS: This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations. RESULTS: The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = -0.22, p = 0.02) and temporal lobe (β = -0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume. CONCLUSION: The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.
Authors: Lachlan T Strike; Baptiste Couvy-Duchesne; Narelle K Hansell; Gabriel Cuellar-Partida; Sarah E Medland; Margaret J Wright Journal: Neuropsychol Rev Date: 2015-03-14 Impact factor: 7.444
Authors: Belinda M Brown; Stephanie R Rainey-Smith; Victor L Villemagne; Michael Weinborn; Romola S Bucks; Hamid R Sohrabi; Simon M Laws; Kevin Taddei; S Lance Macaulay; David Ames; Christopher Fowler; Paul Maruff; Colin L Masters; Christopher C Rowe; Ralph N Martins Journal: Sleep Date: 2016-05-01 Impact factor: 5.849
Authors: Stephanie A Schultz; Elizabeth A Boots; Burcu F Darst; Henrik Zetterberg; Kaj Blennow; Dorothy F Edwards; Rebecca L Koscik; Cynthia M Carlsson; Catherine L Gallagher; Barbara B Bendlin; Sanjay Asthana; Mark A Sager; Kirk J Hogan; Bruce P Hermann; Dane B Cook; Sterling C Johnson; Corinne D Engelman; Ozioma C Okonkwo Journal: Neurology Date: 2017-03-24 Impact factor: 9.910
Authors: Christopher Fowler; Stephanie R Rainey-Smith; Sabine Bird; Julia Bomke; Pierrick Bourgeat; Belinda M Brown; Samantha C Burnham; Ashley I Bush; Carolyn Chadunow; Steven Collins; James Doecke; Vincent Doré; Kathryn A Ellis; Lis Evered; Amir Fazlollahi; Jurgen Fripp; Samantha L Gardener; Simon Gibson; Robert Grenfell; Elise Harrison; Richard Head; Liang Jin; Adrian Kamer; Fiona Lamb; Nicola T Lautenschlager; Simon M Laws; Qiao-Xin Li; Lucy Lim; Yen Ying Lim; Andrea Louey; S Lance Macaulay; Lucy Mackintosh; Ralph N Martins; Paul Maruff; Colin L Masters; Simon McBride; Lidija Milicic; Madeline Peretti; Kelly Pertile; Tenielle Porter; Morgan Radler; Alan Rembach; Joanne Robertson; Mark Rodrigues; Christopher C Rowe; Rebecca Rumble; Olivier Salvado; Greg Savage; Brendan Silbert; Magdalene Soh; Hamid R Sohrabi; Kevin Taddei; Tania Taddei; Christine Thai; Brett Trounson; Regan Tyrrell; Michael Vacher; Shiji Varghese; Victor L Villemagne; Michael Weinborn; Michael Woodward; Ying Xia; David Ames Journal: J Alzheimers Dis Rep Date: 2021-06-03