Literature DB >> 25186557

"Darwinian" tumor-suppression model unsupported in clinical experience.

Waseem Qasim1, Hubert B Gaspar, Adrian J Thrasher.   

Abstract

Entities:  

Mesh：

Year:  2014        PMID： 25186557      PMCID： PMC4435491          DOI： 10.1038/mt.2014.147

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


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  7 in total

1.  Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

Authors:  Marion G Ott; Manfred Schmidt; Kerstin Schwarzwaelder; Stefan Stein; Ulrich Siler; Ulrike Koehl; Hanno Glimm; Klaus Kühlcke; Andrea Schilz; Hana Kunkel; Sonja Naundorf; Andrea Brinkmann; Annette Deichmann; Marlene Fischer; Claudia Ball; Ingo Pilz; Cynthia Dunbar; Yang Du; Nancy A Jenkins; Neal G Copeland; Ursula Lüthi; Moustapha Hassan; Adrian J Thrasher; Dieter Hoelzer; Christof von Kalle; Reinhard Seger; Manuel Grez
Journal:  Nat Med       Date:  2006-04-02       Impact factor: 53.440

2.  Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.

Authors:  Salima Hacein-Bey-Abina; Alexandrine Garrigue; Gary P Wang; Jean Soulier; Annick Lim; Estelle Morillon; Emmanuelle Clappier; Laure Caccavelli; Eric Delabesse; Kheira Beldjord; Vahid Asnafi; Elizabeth MacIntyre; Liliane Dal Cortivo; Isabelle Radford; Nicole Brousse; François Sigaux; Despina Moshous; Julia Hauer; Arndt Borkhardt; Bernd H Belohradsky; Uwe Wintergerst; Maria C Velez; Lily Leiva; Ricardo Sorensen; Nicolas Wulffraat; Stéphane Blanche; Frederic D Bushman; Alain Fischer; Marina Cavazzana-Calvo
Journal:  J Clin Invest       Date:  2008-09       Impact factor: 14.808

3.  Cell competition is a tumour suppressor mechanism in the thymus.

Authors:  Vera C Martins; Katrin Busch; Dilafruz Juraeva; Carmen Blum; Carolin Ludwig; Volker Rasche; Felix Lasitschka; Sergey E Mastitsky; Benedikt Brors; Thomas Hielscher; Hans Joerg Fehling; Hans-Reimer Rodewald
Journal:  Nature       Date:  2014-05-14       Impact factor: 49.962

4.  Cancer: Darwinian tumour suppression.

Authors:  Eduardo Moreno
Journal:  Nature       Date:  2014-05-14       Impact factor: 49.962

5.  Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity.

Authors:  Christian Jörg Braun; Kaan Boztug; Anna Paruzynski; Maximilian Witzel; Adrian Schwarzer; Michael Rothe; Ute Modlich; Rita Beier; Gudrun Göhring; Doris Steinemann; Raffaele Fronza; Claudia Regina Ball; Reinhard Haemmerle; Sonja Naundorf; Klaus Kühlcke; Martina Rose; Chris Fraser; Liesl Mathias; Rudolf Ferrari; Miguel R Abboud; Waleed Al-Herz; Irina Kondratenko; László Maródi; Hanno Glimm; Brigitte Schlegelberger; Axel Schambach; Michael Heinrich Albert; Manfred Schmidt; Christof von Kalle; Christoph Klein
Journal:  Sci Transl Med       Date:  2014-03-12       Impact factor: 17.956

6.  Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency.

Authors:  Amel Hassan; Pamela Lee; Paraskevi Maggina; Jin Hua Xu; Diana Moreira; Mary Slatter; Zohreh Nademi; Austen Worth; Stuart Adams; Alison Jones; Catherine Cale; Zoe Allwood; Kanchan Rao; Robert Chiesa; Persis Amrolia; Hubert Gaspar; E Graham Davies; Paul Veys; Andrew Gennery; Waseem Qasim
Journal:  J Allergy Clin Immunol       Date:  2014-05-01       Impact factor: 10.793

7.  Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.

Authors:  Steven J Howe; Marc R Mansour; Kerstin Schwarzwaelder; Cynthia Bartholomae; Michael Hubank; Helena Kempski; Martijn H Brugman; Karin Pike-Overzet; Stephen J Chatters; Dick de Ridder; Kimberly C Gilmour; Stuart Adams; Susannah I Thornhill; Kathryn L Parsley; Frank J T Staal; Rosemary E Gale; David C Linch; Jinhua Bayford; Lucie Brown; Michelle Quaye; Christine Kinnon; Philip Ancliff; David K Webb; Manfred Schmidt; Christof von Kalle; H Bobby Gaspar; Adrian J Thrasher
Journal:  J Clin Invest       Date:  2008-09       Impact factor: 14.808
  7 in total
  2 in total

Review 1.  Thymocyte self-renewal and oncogenic risk in immunodeficient mouse models: relevance for human gene therapy clinical trials targeting haematopoietic stem cell populations?

Authors:  Samantha L Ginn; Matthew P McCormack; Ian E Alexander
Journal:  Mamm Genome       Date:  2018-09-04       Impact factor: 2.957

Review 2.  Immune Reconstitution After Gene Therapy Approaches in Patients With X-Linked Severe Combined Immunodeficiency Disease.

Authors:  Elena Blanco; Natalia Izotova; Claire Booth; Adrian James Thrasher
Journal:  Front Immunol       Date:  2020-11-27       Impact factor: 7.561
  2 in total

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