Literature DB >> 25185732

In vitro evaluation of a new drug combination against clinical isolates belonging to the Mycobacterium abscessus complex.

S Singh1, N Bouzinbi, V Chaturvedi, S Godreuil, L Kremer.   

Abstract

The in vitro susceptibility profile to amikacin, linezolid, clarithromycin, imipenem, cefoxitin, clofazimine and tigecycline was established for 67 strains belonging to the Mycobacterium abscessus complex. Clofazimine and tigecycline were among the most effective drugs, prompting us to assess the effect of a clofazimine and tigecycline combination. Synergistic activity was found in 42% of the 19 isolates tested. The clinical impact of this new drug combination against the M. abscessus complex, as an alternative or sequential medication for the treatment of drug-resistant strains, remains to be addressed.
© 2014 The Authors Clinical Microbiology and Infection © 2014 European Society of Clinical Microbiology and Infectious Diseases.

Entities:  

Keywords:  Clofazimine; Mycobacterium abscessus; cystic fibrosis; drug susceptibility; tigecycline

Mesh：

Substances：

Year:  2014        PMID： 25185732     DOI： 10.1111/1469-0691.12780

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  24 in total

1.  Synergistic Efficacy of β-Lactam Combinations against Mycobacterium abscessus Pulmonary Infection in Mice.

Authors:  Elizabeth Story-Roller; Emily C Maggioncalda; Gyanu Lamichhane
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish.

Authors:  Christian Dupont; Albertus Viljoen; Sangeeta Thomas; Françoise Roquet-Banères; Jean-Louis Herrmann; Kevin Pethe; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

3.  Clofazimine-Containing Regimen for the Treatment of Mycobacterium abscessus Lung Disease.

Authors:  Bumhee Yang; Byung Woo Jhun; Seong Mi Moon; Hyun Lee; Hye Yun Park; Kyeongman Jeon; Dae Hun Kim; Su-Young Kim; Sung Jae Shin; Charles L Daley; Won-Jung Koh
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

4.  Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.

Authors:  Iman Halloum; Albertus Viljoen; Varun Khanna; Derek Craig; Christiane Bouchier; Roland Brosch; Geoffrey Coxon; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

5.  Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.

Authors:  Matthias Richard; Ana Victoria Gutiérrez; Albertus Viljoen; Daniela Rodriguez-Rincon; Françoise Roquet-Baneres; Mickael Blaise; Isobel Everall; Julian Parkhill; R Andres Floto; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

6.  The TetR Family Transcription Factor MAB_2299c Regulates the Expression of Two Distinct MmpS-MmpL Efflux Pumps Involved in Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.

Authors:  Ana Victoria Gutiérrez; Matthias Richard; Françoise Roquet-Banères; Albertus Viljoen; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

7.  Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro.

Authors:  Hannelore I Bax; Irma A J M Bakker-Woudenberg; Marian T Ten Kate; Annelies Verbon; Jurriaan E M de Steenwinkel
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

8.  Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.

Authors:  Clément Raynaud; Wassim Daher; Françoise Roquet-Banères; Matt D Johansen; Jozef Stec; Oluseye K Onajole; Diane Ordway; Alan P Kozikowski; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

Review 9.  NTM drug discovery: status, gaps and the way forward.

Authors:  Mu-Lu Wu; Dinah B Aziz; Véronique Dartois; Thomas Dick
Journal:  Drug Discov Today       Date:  2018-04-07       Impact factor: 7.851

Review 10.  Mycobacterium abscessus Complex Infections in Children: A Review.

Authors:  Arick P Sabin; Patricia Ferrieri; Susan Kline
Journal:  Curr Infect Dis Rep       Date:  2017-10-05       Impact factor: 3.725
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