Per Sjögren1, Rachel Fisher2, Lena Kallings3, Ulrika Svenson4, Göran Roos4, Mai-Lis Hellénius5. 1. Unit of Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. 2. Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. 3. Department of Sport and Health Sciences, Swedish School of Sport and Health Sciences, Stockholm, Sweden. 4. Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden. 5. Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
Abstract
BACKGROUND:Telomere length has been associated with a healthy lifestyle and longevity. However, the effect of increased physical activity on telomere length is still unknown. Therefore, the aim was to study the relationship between changes in physical activity level and sedentary behaviour and changes in telomere length. METHODS:Telomere length was measured in blood cells 6 months apart in 49, 68-year-old, sedentary, overweight individuals taking part in a randomised controlled physical activity intervention trial. The intervention group received individualised physical activity on prescription. Physical activity was measured with a 7-day diary, questionnaires and a pedometer. Sitting time was measured with the short version of The International Physical Activity Questionnaire. RESULTS:Time spent exercising as well as steps per day increased significantly in the intervention group. Reported sitting time decreased in both groups. No significant associations between changes in steps per day and changes in telomere length were noted. In the intervention group, there was a negative correlation between changes in time spent exercising and changes in telomere length (rho=-0.39, p=0.07). On the other hand, in the intervention group, telomere lengthening was significantly associated with reduced sitting time (rho=-0.68, p=0.02). CONCLUSIONS:Reduced sitting time was associated with telomere lengthening in blood cells in sedentary, overweight 68-year-old individuals participating in a 6-month physical activity intervention trial. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
RCT Entities:
BACKGROUND: Telomere length has been associated with a healthy lifestyle and longevity. However, the effect of increased physical activity on telomere length is still unknown. Therefore, the aim was to study the relationship between changes in physical activity level and sedentary behaviour and changes in telomere length. METHODS: Telomere length was measured in blood cells 6 months apart in 49, 68-year-old, sedentary, overweight individuals taking part in a randomised controlled physical activity intervention trial. The intervention group received individualised physical activity on prescription. Physical activity was measured with a 7-day diary, questionnaires and a pedometer. Sitting time was measured with the short version of The International Physical Activity Questionnaire. RESULTS: Time spent exercising as well as steps per day increased significantly in the intervention group. Reported sitting time decreased in both groups. No significant associations between changes in steps per day and changes in telomere length were noted. In the intervention group, there was a negative correlation between changes in time spent exercising and changes in telomere length (rho=-0.39, p=0.07). On the other hand, in the intervention group, telomere lengthening was significantly associated with reduced sitting time (rho=-0.68, p=0.02). CONCLUSIONS: Reduced sitting time was associated with telomere lengthening in blood cells in sedentary, overweight 68-year-old individuals participating in a 6-month physical activity intervention trial. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Aladdin H Shadyab; Caroline A Macera; Richard A Shaffer; Sonia Jain; Linda C Gallo; Michael J LaMonte; Alexander P Reiner; Charles Kooperberg; Cara L Carty; Chongzhi Di; Todd M Manini; Lifang Hou; Andrea Z LaCroix Journal: Am J Epidemiol Date: 2017-02-01 Impact factor: 4.897
Authors: Shilpa Dogra; Maureen C Ashe; Stuart J H Biddle; Wendy J Brown; Matthew P Buman; Sebastien Chastin; Paul A Gardiner; Shigeru Inoue; Barbara J Jefferis; Koichiro Oka; Neville Owen; Luís B Sardinha; Dawn A Skelton; Takemi Sugiyama; Jennifer L Copeland Journal: Br J Sports Med Date: 2017-07-19 Impact factor: 13.800