Literature DB >> 25183937

What if Fleming had not discovered penicillin?

Sulaiman Ali Alharbi1, Milton Wainwright2, Tahani Awad Alahmadi3, Hashim Bin Salleeh3, Asmaa A Faden4, Arunachalam Chinnathambi1.   

Abstract

What would have happened had Alexander Fleming not discovered penicillin in 1928? Perhaps the obvious answer is that, someone else would have discovered penicillin during 1930s and the Oxford group, would still have purified it sometime in the early 1940s. Here, however, in this counterfactual account of the penicillin story, it is argued that without Fleming, penicillin might still be undiscovered and the antibiotic age would never have dawned. As a result, many of the recent developments in medicine, such as organ transplantation, might have been delayed or, at best, made more hazardous. Penicillin might have come onto the scene a few years later but, had Fleming overlooked the discovery, it seems certain that penicillin would not have saved countless Allied lives, during and after D-Day. Instead of having enjoyed fifty and more years of the antibiotic age, it is argued here, that we would have had to rely upon highly developed sulphonamides, so-called "supasulfas", and other chemically-derived antibacterial drugs. Indeed, it might be the case that, even well into this new millennium, the antibiotic age has yet to dawn, and medicine is still waiting for someone to chance upon penicillin. Here we discuss what might have happened had Fleming not discovered penicillin and come to the conclusion that the medical armoury available today would have been far different and might have relied solely upon highly developed varieties of sulphonamides or similar, synthetic, non-antibiotic antibacterial agents.

Entities:  

Keywords:  Alexander Fleming; Novel antibiotics; Penicillin; Supasulfas

Year:  2014        PMID: 25183937      PMCID: PMC4150221          DOI: 10.1016/j.sjbs.2013.12.007

Source DB:  PubMed          Journal:  Saudi J Biol Sci        ISSN: 1319-562X            Impact factor:   4.219


  7 in total

1.  Alexander Fleming and the discovery of penicillin.

Authors:  J W Bennett; K T Chung
Journal:  Adv Appl Microbiol       Date:  2001       Impact factor: 5.086

2.  Hitler's penicillin.

Authors:  Milton Wainwright
Journal:  Perspect Biol Med       Date:  2004       Impact factor: 1.416

3.  The true history of the discovery of penicillin, with refutation of the misinformation in the literature.

Authors:  F W Diggins
Journal:  Br J Biomed Sci       Date:  1999       Impact factor: 3.829

4.  Penicillin: its discovery and early development.

Authors:  B Lee Ligon
Journal:  Semin Pediatr Infect Dis       Date:  2004-01

5.  C.G. Paine and the earliest surviving clinical records of penicillin therapy.

Authors:  M Wainwright; H T Swan
Journal:  Med Hist       Date:  1986-01       Impact factor: 1.419

6.  New light on the history of penicillin.

Authors:  R Hare
Journal:  Med Hist       Date:  1982-01       Impact factor: 1.419

7.  The history of the therapeutic use of crude penicillin.

Authors:  M Wainwright
Journal:  Med Hist       Date:  1987-01       Impact factor: 1.419

  7 in total
  4 in total

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Authors:  Yugen Zhu; Lakota Cleaver; Wei Wang; Jessica D Podoll; Shane Walls; Austin Jolly; Xiang Wang
Journal:  Eur J Med Chem       Date:  2016-09-10       Impact factor: 6.514

2.  Knowledge, attitude, and practices of health-care providers toward antibiotic prescribing, antibiotic resistance, and multidrug-resistant tuberculosis.

Authors:  Ashna Malhotra; Vimal Kumar; Deepak Juyal; Deepak Gautam; Rajesh Malhotra
Journal:  Perspect Clin Res       Date:  2021-01-08

Review 3.  The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.

Authors:  Bee Ha Gan; Josephine Gaynord; Sam M Rowe; Tomas Deingruber; David R Spring
Journal:  Chem Soc Rev       Date:  2021-07-05       Impact factor: 54.564

4.  Hey surgeons! It is time to lead and be a champion in preventing and managing surgical infections!

Authors:  Massimo Sartelli; Federico Coccolini; Fikri M Abu-Zidan; Luca Ansaloni; Stefano Bartoli; Walter Biffl; Felice Borghi; Elie Chouillard; Yunfeng Cui; Rafael De Oliveira Nascimento; Belinda De Simone; Salomone Di Saverio; Therese Duane; Christian Eckmann; Hani O Eid; Carlos Augusto Gomes; Felipe Couto Gomes; Andreas Hecker; Birgit Hecker; Arda Isik; Kamal M F Itani; Ari Leppaniemi; Andrey Litvin; Davide Luppi; Ronald Maier; Ramiro Manzano-Nunez; Sanjay Marwah; John Mazuski; Ernest Moore; Gennaro Perrone; Kemal Rasa; Ines Rubio; Robert Sawyer; Francesco M Labricciosa; Fausto Catena
Journal:  World J Emerg Surg       Date:  2020-04-19       Impact factor: 5.469

  4 in total

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