Yumako Miura1, Nortina Shahrizaila2, Nobuhiro Yuki3. 1. 1 Department of Medicine, National University of Singapore, Singapore 2 Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Sciences, Yonago, Japan. 2. 3 Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 3. 1 Department of Medicine, National University of Singapore, Singapore 4 Department of Physiology, National University of Singapore, Singapore mdcyuki@nus.edu.sg.