OBJECTIVES: The purpose of this study is to investigate the impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the level of fasting and postprandial serum glucagon-like peptide-1 (GLP-1) in type 2 diabetic mellitus rats. METHODS: Randomized block design, factorial experiment. Forty-five type 2 diabetic rats were divided into four groups: sham operation (S, n = 10) and sham operation with the hepatic branch of the vagotomy (SV, n = 11), Roux-en-Y gastric bypass (RYGB, n = 12) and RYGB without preservation of the vagus (RYGBV, n = 12). Levels of fasting and postprandial serum GLP-1 30 min after 50 % glucose solution (2 g/kg) by gavage were determined before surgery and postoperatively at 1, 4, and 8 weeks. Interactions between RYGB and the common hepatic branch were also assessed. RESULTS: Roux-en-Y gastric bypass surgery significantly increased the concentration of postprandial serum GLP-1 and maintained it at a higher level (P < 0.05). Preservation of vagus hepatic branch only increased the concentration of postprandial serum GLP-1 at the initial stage (P < 0.05), which gradually weakened over time (P > 0.05). Both RYGB and vagotomy of the hepatic branch had no influence on fasting serum GLP-1 (P > 0.05). CONCLUSIONS: During RYGB surgery for the long-term treatment of T2DM, preservation of the hepatic branch of the vagus might have no impact on serum GLP-1 level.
OBJECTIVES: The purpose of this study is to investigate the impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the level of fasting and postprandial serum glucagon-like peptide-1 (GLP-1) in type 2 diabetic mellitusrats. METHODS: Randomized block design, factorial experiment. Forty-five type 2 diabeticrats were divided into four groups: sham operation (S, n = 10) and sham operation with the hepatic branch of the vagotomy (SV, n = 11), Roux-en-Y gastric bypass (RYGB, n = 12) and RYGB without preservation of the vagus (RYGBV, n = 12). Levels of fasting and postprandial serum GLP-1 30 min after 50 % glucose solution (2 g/kg) by gavage were determined before surgery and postoperatively at 1, 4, and 8 weeks. Interactions between RYGB and the common hepatic branch were also assessed. RESULTS: Roux-en-Y gastric bypass surgery significantly increased the concentration of postprandial serum GLP-1 and maintained it at a higher level (P < 0.05). Preservation of vagus hepatic branch only increased the concentration of postprandial serum GLP-1 at the initial stage (P < 0.05), which gradually weakened over time (P > 0.05). Both RYGB and vagotomy of the hepatic branch had no influence on fasting serum GLP-1 (P > 0.05). CONCLUSIONS: During RYGB surgery for the long-term treatment of T2DM, preservation of the hepatic branch of the vagus might have no impact on serum GLP-1 level.
Authors: Tony K T Lam; Alessandro Pocai; Roger Gutierrez-Juarez; Silvana Obici; Joseph Bryan; Lydia Aguilar-Bryan; Gary J Schwartz; Luciano Rossetti Journal: Nat Med Date: 2005-02-27 Impact factor: 53.440
Authors: Matthew R Hayes; Scott E Kanoski; Bart C De Jonghe; Theresa M Leichner; Amber L Alhadeff; Samantha M Fortin; Myrtha Arnold; Wolfgang Langhans; Harvey J Grill Journal: Am J Physiol Regul Integr Comp Physiol Date: 2011-08-17 Impact factor: 3.619
Authors: Marco Bueter; Christian Löwenstein; Hutan Ashrafian; Jacquelien Hillebrand; Stephen R Bloom; Torsten Olbers; Thomas Lutz; Carel W le Roux Journal: Obes Surg Date: 2010-01-30 Impact factor: 4.129