OBJECTIVE: To investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDS patients receiving combined antiretroviral therapy (cART). METHODS: A total of 80 Omani AIDS patients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors (46 males and 34 females), average age of 26 years, attending the SQUH Blood Bank, were tested in parallel as a control group. Measurement of the ZAG levels was performed using a competitive enzyme-linked immunosorbent assay and in accordance with the manufacturer's instructions. RESULTS: The ZAG levels were found to be significantly higher among AIDS patients compared to the healthy individuals (P=0.033). A total of 56 (70%) of the AIDS patients were found to have higher levels of ZAG and 16 (20%) AIDS patients were found to have high ZAG levels, which are significantly (P>0.031) associated with weight loss. CONCLUSIONS: ZAG levels are high among Omani AIDS patients on cART and this necessitates the measurement of ZAG on routine basis, as it is associated with weight loss.
OBJECTIVE: To investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDSpatients receiving combined antiretroviral therapy (cART). METHODS: A total of 80 Omani AIDSpatients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors (46 males and 34 females), average age of 26 years, attending the SQUH Blood Bank, were tested in parallel as a control group. Measurement of the ZAG levels was performed using a competitive enzyme-linked immunosorbent assay and in accordance with the manufacturer's instructions. RESULTS: The ZAG levels were found to be significantly higher among AIDSpatients compared to the healthy individuals (P=0.033). A total of 56 (70%) of the AIDSpatients were found to have higher levels of ZAG and 16 (20%) AIDSpatients were found to have high ZAG levels, which are significantly (P>0.031) associated with weight loss. CONCLUSIONS:ZAG levels are high among Omani AIDSpatients on cART and this necessitates the measurement of ZAG on routine basis, as it is associated with weight loss.
Authors: J M Lenhard; E S Furfine; R G Jain; O Ittoop; L A Orband-Miller; S G Blanchard; M A Paulik; J E Weiel Journal: Antiviral Res Date: 2000-08 Impact factor: 5.970
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Authors: V Ceperuelo-Mallafré; X Escoté; C Viladés; J Peraire; P Domingo; E Solano; J J Sirvent; R Pastor; F Tinahones; M Leal; C Richart; J Vendrell; F Vidal; Verónica Alba; Alba Aguilar; Teresa Auguet; Matilde R Chacón; Miguel López-Dupla; Anna Megia; Merce Miranda; Montserrat Olona; Amadeu Saurí; Montserrat Vargas; Ignacio Velasco; Sergi Veloso; Angels Fontanet; Mar Gutiérrez; Gràcia Mateo; Jessica Muñoz; Ma Antònia Sambeat Journal: HIV Med Date: 2012-01-19 Impact factor: 3.180