Abdur Rauf1, Ghias Uddin1, Bina S Siddiqui2, Naveed Muhammad3, Haroon Khan4. 1. Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, KPK, Pakistan. 2. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. 3. Department of Pharmacy, Hazara University, Havelian Campus, Abbottabbad-22500, Pakistan. 4. Gandhara College of Pharmacy, Gandhara University, Peshawar-25120, KPK, Pakistan.
Abstract
OBJECTIVE: To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models. METHODS: In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p. RESULTS: The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane. CONCLUSIONS: In short, our study scientifically validated the traditional use of the plant as antipyretic.
OBJECTIVE: To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models. METHODS: In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p. RESULTS: The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane. CONCLUSIONS: In short, our study scientifically validated the traditional use of the plant as antipyretic.
Authors: Naveed Muhammad; Muhammad Ibrar; Haroon Khan; Muhammad Saeed; Amir Zada Khan; Waqar Ahmad Kaleem Journal: Asian Pac J Trop Biomed Date: 2013-03
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