Azar Hadadi1, Sirous Jafari2, Zahra Hoseini Jebeli3, Reza Hamidian4. 1. Iranian Research Center for HIV/AIDS Institute of High Risk Behavior Reduction, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran ; Internal Medicine Department & Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2. Infectious Diseases Department and Iranian Research Center for HIV/AIDS, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. 3. Candidate for Radiology, Tehran University of Medical Sciences, Tehran, Iran. 4. Research Development Center, Sina hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
OBJECTIVE: To estimate and outline the frequency and etiology of lymphadenopathy in HIV/AIDS patients. METHODS: This study was conducted on 178 consecutive HIV/AIDS patient files for etiologies (categorized into three sub-groups: definite, probable and possible) and associated factors of local and generalized lymphadenopathy. RESULTS: Seventy-two (40.45%) patients including 63 male patients (87.5%) developed lymphadenopathy. HIV in lymphadenopathy(+) patients was most commonly transmitted intravenously (n=49). Generalized and localized lymphadenopathy respectively occurred in 27 (37.50%) and 45 (62.50%) patients, mainly in the cervical region (28.9% for local and 63% for generalized lymphadenopathy). The most common causes of lymphadenopathy were tuberculosis (n=24, 33.3%) and lymphoma (n=12, 16.6%). The frequency of lymphadenopathy was non-significantly higher in patients with AIDS (CD4 count <200 cell/µL) vs. HIV(+) patients (CD4 count >200 cell/µL). CONCLUSIONS: Lymphadenopathy in HIV/AIDS patients may reflect a serious condition, most likely tuberculosis and lymphoma. Since patients might underestimate lymphadenopathy, physicians would rather list these entities for diagnosis.
OBJECTIVE: To estimate and outline the frequency and etiology of lymphadenopathy in HIV/AIDSpatients. METHODS: This study was conducted on 178 consecutive HIV/AIDSpatient files for etiologies (categorized into three sub-groups: definite, probable and possible) and associated factors of local and generalized lymphadenopathy. RESULTS: Seventy-two (40.45%) patients including 63 male patients (87.5%) developed lymphadenopathy. HIV in lymphadenopathy(+) patients was most commonly transmitted intravenously (n=49). Generalized and localized lymphadenopathy respectively occurred in 27 (37.50%) and 45 (62.50%) patients, mainly in the cervical region (28.9% for local and 63% for generalized lymphadenopathy). The most common causes of lymphadenopathy were tuberculosis (n=24, 33.3%) and lymphoma (n=12, 16.6%). The frequency of lymphadenopathy was non-significantly higher in patients with AIDS (CD4 count <200 cell/µL) vs. HIV(+) patients (CD4 count >200 cell/µL). CONCLUSIONS:Lymphadenopathy in HIV/AIDSpatients may reflect a serious condition, most likely tuberculosis and lymphoma. Since patients might underestimate lymphadenopathy, physicians would rather list these entities for diagnosis.
Authors: Ivana S Varella; Ivete C T Canti; Breno R Santos; Angela Z Coppini; Luciana C Argondizzo; Carina Tonin; Mário B Wagner Journal: Mem Inst Oswaldo Cruz Date: 2009-03 Impact factor: 2.743