Literature DB >> 25182763

Cofactor profiling of the glucocorticoid receptor from a cellular environment.

Sofie J Desmet1, Lien Dejager, Dorien Clarisse, Jonathan Thommis, Diana Melchers, Niek Bastiaensen, Rob Ruijtenbeek, Ilse M Beck, Claude Libert, René Houtman, Onno C Meijer, Karolien De Bosscher.   

Abstract

The Microarray Assay for Realtime Coregulator-Nuclear receptor Interaction (MARCoNI) technology allows the identification of nuclear receptor-coregulator interactions via flow-through microarrays. As such, differences in the coregulator profile between distinct nuclear receptors or of a single receptor in agonist or antagonist mode can be investigated, even in a single run. In this chapter, the method how to perform these peptide microarrays with cell lysates containing the overexpressed glucocorticoid receptor is described, as well as the influence of assay parameters, variations to the protocol, and data analysis.

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Year:  2014        PMID： 25182763     DOI： 10.1007/978-1-4939-1346-6_8

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  11 in total

Review 1.  Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.

Authors:  Eva M G Viho; Jacobus C Buurstede; Ahmed Mahfouz; Lisa L Koorneef; Lisa T C M van Weert; René Houtman; Hazel J Hunt; Jan Kroon; Onno C Meijer
Journal:  Neuroendocrinology       Date:  2019-03-19       Impact factor: 4.914

2.  ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer.

Authors:  Laura Cato; Jonas de Tribolet-Hardy; Irene Lee; Jaice T Rottenberg; Ilsa Coleman; Diana Melchers; René Houtman; Tengfei Xiao; Wei Li; Takuma Uo; Shihua Sun; Nane C Kuznik; Bettina Göppert; Fatma Ozgun; Martin E van Royen; Adriaan B Houtsmuller; Raga Vadhi; Prakash K Rao; Lewyn Li; Steven P Balk; Robert B Den; Bruce J Trock; R Jeffrey Karnes; Robert B Jenkins; Eric A Klein; Elai Davicioni; Friederike J Gruhl; Henry W Long; X Shirley Liu; Andrew C B Cato; Nathan A Lack; Peter S Nelson; Stephen R Plymate; Anna C Groner; Myles Brown
Journal:  Cancer Cell       Date:  2019-02-14       Impact factor: 31.743

3.  Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer.

Authors:  Diana C West; Masha Kocherginsky; Eva Y Tonsing-Carter; D Nesli Dolcen; David J Hosfield; Ricardo R Lastra; Jason P Sinnwell; Kevin J Thompson; Kathleen R Bowie; Ryan V Harkless; Maxwell N Skor; Charles F Pierce; Sarah C Styke; Caroline R Kim; Larischa de Wet; Geoffrey L Greene; Judy C Boughey; Matthew P Goetz; Krishna R Kalari; Liewei Wang; Gini F Fleming; Balázs Györffy; Suzanne D Conzen
Journal:  Clin Cancer Res       Date:  2018-04-10       Impact factor: 12.531

Review 4.  Endothelial Response to Glucocorticoids in Inflammatory Diseases.

Authors:  Karolina A Zielińska; Laura Van Moortel; Ghislain Opdenakker; Karolien De Bosscher; Philippe E Van den Steen
Journal:  Front Immunol       Date:  2016-12-14       Impact factor: 7.561

5.  Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies.

Authors:  Dorien Clarisse; Jonathan Thommis; Karlien Van Wesemael; René Houtman; Dariusz Ratman; Jan Tavernier; Fritz Offner; Ilse Beck; Karolien De Bosscher
Journal:  Oncotarget       Date:  2017-11-30

6.  Compound A influences gene regulation of the Dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment.

Authors:  S J Desmet; N Bougarne; L Van Moortel; L De Cauwer; J Thommis; M Vuylsteke; D Ratman; R Houtman; J Tavernier; K De Bosscher
Journal:  Sci Rep       Date:  2017-08-14       Impact factor: 4.379

7.  Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

Authors:  Ruth A Morgan; Katharina R Beck; Mark Nixon; Natalie Z M Homer; Andrew A Crawford; Diana Melchers; René Houtman; Onno C Meijer; Andreas Stomby; Anna J Anderson; Rita Upreti; Roland H Stimson; Tommy Olsson; Tom Michoel; Ariella Cohain; Arno Ruusalepp; Eric E Schadt; Johan L M Björkegren; Ruth Andrew; Christopher J Kenyon; Patrick W F Hadoke; Alex Odermatt; John A Keen; Brian R Walker
Journal:  Sci Rep       Date:  2017-09-06       Impact factor: 4.379

8.  Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads.

Authors:  Chandra S Chirumamilla; Ajay Palagani; Balu Kamaraj; Ken Declerck; Marinus W C Verbeek; Ryabtsova Oksana; Karolien De Bosscher; Nadia Bougarne; Bart Ruttens; Kris Gevaert; René Houtman; Winnok H De Vos; Jurgen Joossens; Pieter Van Der Veken; Koen Augustyns; Xaveer Van Ostade; Annemie Bogaerts; Hans De Winter; Wim Vanden Berghe
Journal:  Front Immunol       Date:  2017-11-01       Impact factor: 7.561

Review 9.  Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective.

Authors:  Anne-Sophie C A M Koning; Jacobus C Buurstede; Lisa T C M van Weert; Onno C Meijer
Journal:  J Endocr Soc       Date:  2019-07-24

10.  The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity.

Authors:  Lisa L Koorneef; Jan Kroon; Eva M G Viho; Lucas F Wahl; Kim M L Heckmans; Marloes M A R van Dorst; Menno Hoekstra; René Houtman; Hazel Hunt; Onno C Meijer
Journal:  J Endocrinol       Date:  2020-07       Impact factor: 4.286
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