Literature DB >> 25182634

Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms.

Donavon J Hess1, Michelle J Henry-Stanley2, Carol L Wells3.   

Abstract

Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID: 25182634      PMCID: PMC4249351          DOI: 10.1128/AAC.03672-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  24 in total

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5.  The EPS matrix: the "house of biofilm cells".

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Review 6.  Evolving concepts in biofilm infections.

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