Idris Sherifat Banke1, Ambali Suleiman Folorunsho2, Bisalla Mohammed3, Suleiman Mohammed Musa4, Onukak Charles4, Ayo Joseph Olusegun4. 1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Nigeria. 2. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Nigeria. 3. Department of Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria. 4. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
Abstract
OBJECTIVE: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. METHODS: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) respectively. Group III was administered with melatonin at 0.5 mg/kg only. Group IV was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)], and Group V was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)] 30 min after melatonin (0.5 mg/kg). The regimens were administered by gavage once daily for 12 weeks. Thereafter, cognitive performances were determined and the brain was evaluated for malonaldehyde concentration. RESULTS: CPF and CYP induced cognitive deficits and increased brain malonaldehyde concentration, which were all ameliorated by melatonin. CONCLUSION: Cognitive deficits elicited by CPF and CYP was mitigated by melatonin due to its antioxidant property.
OBJECTIVE: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. METHODS: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) respectively. Group III was administered with melatonin at 0.5 mg/kg only. Group IV was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)], and Group V was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)] 30 min after melatonin (0.5 mg/kg). The regimens were administered by gavage once daily for 12 weeks. Thereafter, cognitive performances were determined and the brain was evaluated for malonaldehyde concentration. RESULTS:CPF and CYP induced cognitive deficits and increased brain malonaldehyde concentration, which were all ameliorated by melatonin. CONCLUSION:Cognitive deficits elicited by CPF and CYP was mitigated by melatonin due to its antioxidant property.
Authors: S Gönenç; N Uysal; O Açikgöz; B M Kayatekin; A Sönmez; M Kiray; I Aksu; B Güleçer; A Topçu; I Semin Journal: Physiol Res Date: 2005 Impact factor: 1.881
Authors: David L Eaton; Robert B Daroff; Herman Autrup; James Bridges; Patricia Buffler; Lucio G Costa; Joseph Coyle; Guy McKhann; William C Mobley; Lynn Nadel; Diether Neubert; Rolf Schulte-Hermann; Peter S Spencer Journal: Crit Rev Toxicol Date: 2008 Impact factor: 5.635
Authors: Robin M Whyatt; Virginia Rauh; Dana B Barr; David E Camann; Howard F Andrews; Robin Garfinkel; Lori A Hoepner; Diurka Diaz; Jessica Dietrich; Andria Reyes; Deliang Tang; Patrick L Kinney; Frederica P Perera Journal: Environ Health Perspect Date: 2004-07 Impact factor: 9.031