X Wang1, Y Qian1, B Liu1, L Cao2, Y Fan3, J J Zhang1, Y Yu4. 1. Department of Radiology, Research Institute of Radiological Science, The First Affiliated Hospital, Anhui Medical University, Hefei, China. 2. Department of Pathology, The First Affiliated Hospital, Anhui Medical University, Hefei, China. 3. School of Public Health, Anhui Medical University, Hefei, China. 4. Department of Radiology, Research Institute of Radiological Science, The First Affiliated Hospital, Anhui Medical University, Hefei, China. Electronic address: hfyuyongqiang@hotmail.com.
Abstract
AIM: To compare tumour visibility on diffusion-weighted (DW) images and the diagnostic performance of the apparent diffusion coefficient (ADC) maps obtained using b-values of 1000, 1500, and 2000 s/mm(2). MATERIALS AND METHODS: Forty patients with biopsy-proven prostate cancer were retrospectively included in the study. DWI was examined under different pairs of b-values (b = 0, 1000 s/mm(2); 0, 1500 s/mm(2); and 0, 2000 s/mm(2)) and apparent diffusion coefficient (ADC) maps were generated with a mono-exponential fitting. The tumour-to-normal tissue [in the peripheral gland and transitional gland, peripheral zone (PZ) and central gland] contrast ratio (CR) and prostate tumour signal-to-noise ratio (SNR) were compared between different b-value DWI images. ADC was measured and areas under the receiver operating characteristic curve (Az) were calculated. RESULTS: The CR of the tumour-to-PZ/central gland was significantly higher in the b = 1500 s/mm(2) images than in images created using other b-values (both p < 0.01). The tumour SNR was statistically significantly higher in b = 1500 s/mm(2) images than in the other b-value images (p < 0.01), and was significantly higher in b = 1000 s/mm(2) images than in images created at b = 2000 s/mm(2) (p = 0.035). The Az for b = 1500 s/mm(2) was significantly higher than the Az for b = 2000 s/mm(2) in the PZ (p = 0.016) and central gland (p = 0.037), and higher than the Az for b = 1000 s/mm(2), but not reach statistical significance in the PZ (p = 0.16) and in the central gland (p = 0.23). CONCLUSION: At 3 T MRI, DWI images and ADC maps using b = 1500 s/mm(2) should be considered more effective than those at b = 2000 s/mm(2) or b = 1000 s/mm(2) for detecting prostate cancer.
AIM: To compare tumour visibility on diffusion-weighted (DW) images and the diagnostic performance of the apparent diffusion coefficient (ADC) maps obtained using b-values of 1000, 1500, and 2000 s/mm(2). MATERIALS AND METHODS: Forty patients with biopsy-proven prostate cancer were retrospectively included in the study. DWI was examined under different pairs of b-values (b = 0, 1000 s/mm(2); 0, 1500 s/mm(2); and 0, 2000 s/mm(2)) and apparent diffusion coefficient (ADC) maps were generated with a mono-exponential fitting. The tumour-to-normal tissue [in the peripheral gland and transitional gland, peripheral zone (PZ) and central gland] contrast ratio (CR) and prostate tumour signal-to-noise ratio (SNR) were compared between different b-value DWI images. ADC was measured and areas under the receiver operating characteristic curve (Az) were calculated. RESULTS: The CR of the tumour-to-PZ/central gland was significantly higher in the b = 1500 s/mm(2) images than in images created using other b-values (both p < 0.01). The tumour SNR was statistically significantly higher in b = 1500 s/mm(2) images than in the other b-value images (p < 0.01), and was significantly higher in b = 1000 s/mm(2) images than in images created at b = 2000 s/mm(2) (p = 0.035). The Az for b = 1500 s/mm(2) was significantly higher than the Az for b = 2000 s/mm(2) in the PZ (p = 0.016) and central gland (p = 0.037), and higher than the Az for b = 1000 s/mm(2), but not reach statistical significance in the PZ (p = 0.16) and in the central gland (p = 0.23). CONCLUSION: At 3 T MRI, DWI images and ADC maps using b = 1500 s/mm(2) should be considered more effective than those at b = 2000 s/mm(2) or b = 1000 s/mm(2) for detecting prostate cancer.
Authors: Richard C Wu; Amir H Lebastchi; Boris A Hadaschik; Mark Emberton; Caroline Moore; Pilar Laguna; Jurgen J Fütterer; Arvin K George Journal: World J Urol Date: 2021-01-04 Impact factor: 4.226