Todd A Abruzzo1, James I Geller2, Dale A Kimbrough3, Samantha Michaels2, Zélia M Corrêa4, Kevin Cornell3, James J Augsburger4. 1. Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Mayfield Clinic, Cincinnati, Ohio, USA. 2. Department of Hematology and Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 3. Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 4. Department of Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Abstract
PURPOSE: To develop a reproducible technique for selective ophthalmic artery infusion chemotherapy (SOAIC) that is technically efficacious in children with unfavorable patterns of ophthalmic artery (OA) flow. MATERIALS AND METHODS: Initially, all SOAIC was performed with intention to treat using a standard selective OA (microcatheter) infusion technique (sSOAIC). Temporary balloon occlusion (TBO) of the external carotid artery (ECA), a balloon-assisted SOAIC (bSOAIC) technique, was performed only if OA angiography did not show robust and sustained anterograde OA flow. In our more recent experience, all SOAIC was performed with intention to treat by bSOAIC. Verapamil infusion into the OA and internal carotid artery was performed in selected cases. Technical success was defined as delivery of chemotherapeutic agent(s) into the OA with robust and sustained anterograde perfusion. sSOAIC was considered to have failed if converted to bSOAIC. RESULTS: 19 eyes were treated in 17 patients (age 5 months to 16 years) between December 2008 and May 2013. Eighty-three procedures were undertaken and the OA was successfully catheterized in all. Technical success was achieved in 35/41 (85%) sSOAIC cases and 42/42 (100%) bSOAIC cases. TBO of the ECA augmented anterograde OA flow and converted all cases of retrograde OA flow to anterograde. Verapamil further augmented anterograde ocular perfusion during SOAIC. There were no access site complications, strokes, or deaths. CONCLUSIONS: TBO of the ECA is a safe, effective, and reproducible method for optimizing ocular hemodynamics during SOAIC regardless of baseline OA flow pattern. Verapamil infusion may further favorably modify OA flow. TRIAL REGISTRATION NUMBER: NCT01466855. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
PURPOSE: To develop a reproducible technique for selective ophthalmic artery infusion chemotherapy (SOAIC) that is technically efficacious in children with unfavorable patterns of ophthalmic artery (OA) flow. MATERIALS AND METHODS: Initially, all SOAIC was performed with intention to treat using a standard selective OA (microcatheter) infusion technique (sSOAIC). Temporary balloon occlusion (TBO) of the external carotid artery (ECA), a balloon-assisted SOAIC (bSOAIC) technique, was performed only if OA angiography did not show robust and sustained anterograde OA flow. In our more recent experience, all SOAIC was performed with intention to treat by bSOAIC. Verapamil infusion into the OA and internal carotid artery was performed in selected cases. Technical success was defined as delivery of chemotherapeutic agent(s) into the OA with robust and sustained anterograde perfusion. sSOAIC was considered to have failed if converted to bSOAIC. RESULTS: 19 eyes were treated in 17 patients (age 5 months to 16 years) between December 2008 and May 2013. Eighty-three procedures were undertaken and the OA was successfully catheterized in all. Technical success was achieved in 35/41 (85%) sSOAIC cases and 42/42 (100%) bSOAIC cases. TBO of the ECA augmented anterograde OA flow and converted all cases of retrograde OA flow to anterograde. Verapamil further augmented anterograde ocular perfusion during SOAIC. There were no access site complications, strokes, or deaths. CONCLUSIONS:TBO of the ECA is a safe, effective, and reproducible method for optimizing ocular hemodynamics during SOAIC regardless of baseline OA flow pattern. Verapamil infusion may further favorably modify OA flow. TRIAL REGISTRATION NUMBER: NCT01466855. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Bruno Bartolini; Francesco Puccinelli; Steven D Hajdu; Christina Stathopoulos; Maja Beck-Popovic; Francis L Munier; Guillaume Saliou Journal: Interv Neuroradiol Date: 2018-11-28 Impact factor: 1.610
Authors: Anthony B Daniels; Michael T Froehler; Amy H Nunnally; Janene M Pierce; Ivan Bozic; Cameron A Stone; Pranav R Santapuram; Yuankai K Tao; Kelli L Boyd; Lauren E Himmel; Sheau-Chiann Chen; Liping Du; Debra L Friedman; Ann Richmond Journal: Invest Ophthalmol Vis Sci Date: 2019-03-01 Impact factor: 4.799
Authors: T Abruzzo; K Abraham; K B Karani; J I Geller; S Vadivelu; J M Racadio; B Zhang; Z M Correa Journal: AJNR Am J Neuroradiol Date: 2020-12-24 Impact factor: 3.825