Literature DB >> 25179279

Keratan sulfate: an up-to-date review.

Vitor H Pomin1.   

Abstract

Keratan sulfate (KS) is a glycosaminoglycan (GAG) type consisted of a sulfated poly-N-acetyl lactosamine chain. Besides acting as a constitutive molecule of the extracellular matrices, this GAG also plays a role as a hydrating and signaling agent in cornea and cartilage tissues. Inasmuch, KS is widely explored in the pharmaceutical industry. This review will cover the major achievements described in the literature of 2010-2014 concerning this GAG. Discussion about KS' roles in physiopathological conditions, as target or therapeutic molecule in diseases, methods of analysis and detection as well as KS-related enzymes, metabolism and developmental biology is properly provided.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Carbohydrate-based drug; Cartilage; Eye drop; Glycosaminoglycan; Inflammation; Keratan sulfate

Mesh：

Substances：

Year:  2014        PMID： 25179279     DOI： 10.1016/j.ijbiomac.2014.08.029

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  31 in total

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