| Literature DB >> 25178783 |
Keng Cher Soh1, Vassily Hatzimanikatis.
Abstract
Flux balance analysis of stoichiometric metabolic models has become one of the most common methods for estimating intracellular fluxes. However most of these networks are underdetermined and can have multiple alternate optimal flux distributions. Thermodynamic constraints can reduce the solution space significantly and at the same time provide a platform for the integration of metabolomics data. Here we go through the procedure to incorporate thermodynamic constraints and perform thermodynamic analysis of metabolic networks.Mesh：
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Year: 2014 PMID： 25178783 DOI： 10.1007/978-1-4939-1170-7_3
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745