Literature DB >> 25177619

Granulocytic sarcoma with compressive myelopathy: a rare presentation of chronic myelogenous leukemia.

Abhijeet P Ganapule1, Auro Viswabandya2, Anita Jasper3, Palak Patel4, Gautami Kokil5.   

Abstract

Granulocytic sarcoma occurs most commonly in acute myelogenous leukemia. The appearance of granulocytic sarcoma in chronic myelogenous leukemia signals accelerated phase/ blast transformation. This is a rare case of undiagnosed chronic myelogenous leukemia with granulocytic sarcoma causing cord compression, which went into tumour lysis syndrome requiring dialysis after starting of steroids and radiotherapy. A 43-year-old male presented in emergency department with acute onset of flaccid paralysis. On clinical examination, there was hepatosplenomegaly and lower motor neuron paralysis in the lower limbs. The peripheral smear was consistent with chronic myelogenous leukemia in chronic phase. The MRI spine revealed para-spinal and epidural masses causing cord compression and the biopsy from the paraspinal mass was consistent with granulocytic sarcoma.

Entities:  

Keywords:  Cord compression; Granulocytic sarcoma; Tumour lysis syndrome

Year:  2014        PMID: 25177619      PMCID: PMC4149125          DOI: 10.7860/JCDR/2014/9319.4640

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  6 in total

1.  A population-based study of malignant spinal cord compression in Ontario.

Authors:  D A Loblaw; N J Laperriere; W J Mackillop
Journal:  Clin Oncol (R Coll Radiol)       Date:  2003-06       Impact factor: 4.126

2.  Spinal epidural leukemia.

Authors:  D E WILHYDE; J A JANE; S MULLAN
Journal:  Am J Med       Date:  1963-02       Impact factor: 4.965

3.  Unusual presentation of acute myeloid leukemia.

Authors:  P D Anjaria; U G Gadgil; S M Gaikwad
Journal:  J Postgrad Med       Date:  1976-01       Impact factor: 1.476

4.  A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease.

Authors:  Paul Klimo; Clinton J Thompson; John R W Kestle; Meic H Schmidt
Journal:  Neuro Oncol       Date:  2005-01       Impact factor: 12.300

5.  Paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia.

Authors:  Barbara J Bryant; Jack B Alperin; M Tarek Elghetany
Journal:  Am J Hematol       Date:  2007-02       Impact factor: 10.047

Review 6.  Granulocytic sarcoma: an unusual complication of aleukemic myeloid leukemia causing spinal cord compression. A case report and literature review.

Authors:  Daniel M Landis; David M Aboulafia
Journal:  Leuk Lymphoma       Date:  2003-10
  6 in total
  1 in total

Review 1.  Granulocytic sarcoma causing long spinal cord compression: Case report and literature review.

Authors:  Shiyuan Han; Yongning Li; Tong Niu; Xin Wang; Zhimin Li; Xinyu Ren; Jun Gao
Journal:  J Spinal Cord Med       Date:  2020-06-16       Impact factor: 2.040

  1 in total

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