Yongjia Yan1, Li Lu2, Chunna Liu2, Weidong Li1, Tong Liu1, Weihua Fu3. 1. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China. 2. Tianjin Medical University, Tianjin 300070, China. 3. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: drfuweihua@gmail.com.
Abstract
PURPOSE: Human epidermal growth factor receptor 2 (HER2/neu) is involved in the pathogenesis of several types of cancer, including gastric cancer. However, there remains a paucity of data regarding the prognostic relevance of HER2/neu in early gastric cancer without lymph node metastasis (pN0 EGC). The aim of our study was to analyze whether the over-expression of HER2/neu significantly predicts poor outcomes of pN0 EGC. PATIENTS AND METHODS: Sixty-seven patients who underwent operative resection for pN0 EGC was enrolled. The HER2/neu status was examined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). RESULTS: The HER2/neu-positive rate was 16.4%. HER2/neu over-expression showed a significant correlation with histological type (P ≤ 0.001), tumor location (P=0.022) and Lauren grade (P=0.012). Multivariate analysis showed HER2/neu serves as a good prognostic marker to predict the risk of poor outcome for pN0 EGC. (HR=1.384, 95.0% CI: 1.142-1.897 P=0.005) CONCLUSION: Considering HER2/neu over-expression significantly predicts poor outcome in pN0 EGC, accurate HER2/neu assessment would be done before endoscopic therapy. For HER2/neu-positive patients, radical surgery should be performed.
PURPOSE:Humanepidermal growth factor receptor 2 (HER2/neu) is involved in the pathogenesis of several types of cancer, including gastric cancer. However, there remains a paucity of data regarding the prognostic relevance of HER2/neu in early gastric cancer without lymph node metastasis (pN0 EGC). The aim of our study was to analyze whether the over-expression of HER2/neu significantly predicts poor outcomes of pN0 EGC. PATIENTS AND METHODS: Sixty-seven patients who underwent operative resection for pN0 EGC was enrolled. The HER2/neu status was examined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). RESULTS: The HER2/neu-positive rate was 16.4%. HER2/neu over-expression showed a significant correlation with histological type (P ≤ 0.001), tumor location (P=0.022) and Lauren grade (P=0.012). Multivariate analysis showed HER2/neu serves as a good prognostic marker to predict the risk of poor outcome for pN0 EGC. (HR=1.384, 95.0% CI: 1.142-1.897 P=0.005) CONCLUSION: Considering HER2/neu over-expression significantly predicts poor outcome in pN0 EGC, accurate HER2/neu assessment would be done before endoscopic therapy. For HER2/neu-positive patients, radical surgery should be performed.
Authors: K A Kurdziel; E Mena; Y McKinney; K Wong; S Adler; T Sissung; J Lee; S Lipkowitz; L Lindenberg; B Turkbey; S Kummar; D E Milenic; J H Doroshow; W D Figg; M J Merino; C H Paik; M W Brechbiel; P L Choyke Journal: J Transl Sci Date: 2018-07-13