Literature DB >> 25176577

Imaging of doxorubicin release from theranostic macromolecular prodrugs via fluorescence resonance energy transfer.

Harald R Krüger1, Irene Schütz2, Aileen Justies1, Kai Licha3, Pia Welker3, Volker Haucke2, Marcelo Calderón4.   

Abstract

Herein we present a FRET-based theranostic macromolecular prodrug (TMP) composed of (a) dendritic polyglycerol (PG) as polymeric nanocarrier, (b) doxorubicin (Dox) linked via a pH-sensitive hydrazone to (c) a tri-functional linker, and (d) an indodicarbocyanine dye (IDCC) attached in close proximity to Dox. The drug fluorescence is quenched via intramolecular FRET until the pH-sensitive hydrazone bond between the TMP and Dox is cleaved at acidic pH. By measuring its fluorescence, we characterized the TMP cleavage kinetics at different pH values in vitro. The intracellular release of Dox from the carrier was monitored in real time in intact cancer cells, giving more insight into the mode of action of a polymer drug conjugate.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Drug delivery; FRET imaging; Intracellular release; Polymer therapeutic

Mesh：

Substances：

Year:  2014        PMID： 25176577     DOI： 10.1016/j.jconrel.2014.08.018

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  10 in total

1.  Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.

Authors:  Wei Fan; Wen Shi; Wenting Zhang; Yinnong Jia; Zhengyuan Zhou; Susan K Brusnahan; Jered C Garrison
Journal:  Biomaterials       Date:  2016-06-08       Impact factor: 12.479

2.  A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles.

Authors:  Jing Wang; Jayanta Bhattacharyya; Eric Mastria; Ashutosh Chilkoti
Journal:  J Control Release       Date:  2017-05-30       Impact factor: 9.776

3.  Thermosensitive porphyrin-incorporated hydrogel with four-arm PEG-PCL copolymer (II): doxorubicin loaded hydrogel as a dual fluorescent drug delivery system for simultaneous imaging tracking in vivo.

Authors:  Xia Dong; Hongli Chen; Jingwen Qin; Chang Wei; Jie Liang; Tianjun Liu; Deling Kong; Feng Lv
Journal:  Drug Deliv       Date:  2017-11       Impact factor: 6.419

4.  Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy.

Authors:  Vijaya Sarangthem; Yunjae Kim; Thoudam Debraj Singh; Bo-Yeon Seo; Sun-Ha Cheon; Young-Jin Lee; Byung-Heon Lee; Rang-Woon Park
Journal:  Theranostics       Date:  2016-09-25       Impact factor: 11.556

5.  A pH-sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier.

Authors:  Stefan Aichhorn; Anne Linhardt; Angela Halfmann; Markus Nadlinger; Stefanie Kirchberger; Manuela Stadler; Barbara Dillinger; Martin Distel; Alexander Dohnal; Ian Teasdale; Wolfgang Schöfberger
Journal:  Chemistry       Date:  2017-09-04       Impact factor: 5.236

Review 6.  Polyglycerols as Multi-Functional Platforms: Synthesis and Biomedical Applications.

Authors:  Paria Pouyan; Mariam Cherri; Rainer Haag
Journal:  Polymers (Basel)       Date:  2022-06-30       Impact factor: 4.967

Review 7.  Dendritic Polymers for Theranostics.

Authors:  Yuan Ma; Quanbing Mou; Dali Wang; Xinyuan Zhu; Deyue Yan
Journal:  Theranostics       Date:  2016-04-27       Impact factor: 11.556

8.  Dual turn-on fluorescence signal-based controlled release system for real-time monitoring of drug release dynamics in living cells and tumor tissues.

Authors:  Xiuqi Kong; Baoli Dong; Xuezhen Song; Chao Wang; Nan Zhang; Weiying Lin
Journal:  Theranostics       Date:  2018-01-01       Impact factor: 11.556

9.  Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome.

Authors:  Shiran Ferber; Galia Tiram; Ana Sousa-Herves; Anat Eldar-Boock; Adva Krivitsky; Anna Scomparin; Eilam Yeini; Paula Ofek; Dikla Ben-Shushan; Laura Isabel Vossen; Kai Licha; Rachel Grossman; Zvi Ram; Jack Henkin; Eytan Ruppin; Noam Auslander; Rainer Haag; Marcelo Calderón; Ronit Satchi-Fainaro
Journal:  Elife       Date:  2017-10-04       Impact factor: 8.140

10.  Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model.

Authors:  Gregor Nagel; Ana Sousa-Herves; Stefanie Wedepohl; Marcelo Calderón
Journal:  Theranostics       Date:  2020-01-01       Impact factor: 11.556
  10 in total

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