| Literature DB >> 2517587 |
S C Davino1, A M Giesbrecht, N F Roque.
Abstract
The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid derivatives substituted on carbon-15. Only acetylgrandifloric acid (ent-kaur-16-en-15 alpha-acetyloxy-19-oic) and its epimer xylopic acid (ent-kaur-16-en-15 beta-acetyloxy-19-oic) displayed significant antibacterial activity at concentrations greater than or equal to 250 micrograms/ml, the 15 alpha epimer being the most active.Entities:
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Year: 1989 PMID： 2517587
Source DB: PubMed Journal: Braz J Med Biol Res ISSN： 0100-879X Impact factor: 2.590