Literature DB >> 25175163

Heptamethoxyflavone, a citrus flavonoid, suppresses inflammatory osteoclastogenesis and alveolar bone resorption.

Chiho Matsumoto1, Hiroki Inoue, Tsukasa Tominari, Kenta Watanabe, Michiko Hirata, Chisato Miyaura, Masaki Inada.   

Abstract

We examined the effects of heptamethoxyflavone (HMF), a citrus flavonoid on inflammatory bone resorption. HMF suppressed the osteoclast formation and PGE2 production induced by IL-1. In mouse calvarial organ cultures, HMF attenuated the bone resorption elicited by LPS. HMF suppressed bone resorption in the mandibular alveolar bone. HMF may protect against inflammatory bone loss such as periodontal disease.

Entities:  

Keywords:  heptamethoxyflavone; inflammatory bone loss; osteoclast; periodontal disease

Mesh：

Substances：

Year:  2014        PMID： 25175163     DOI： 10.1080/09168451.2014.952616

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  2 in total

1.  Effects of Polymethoxyflavonoids on Bone Loss Induced by Estrogen Deficiency and by LPS-Dependent Inflammation in Mice.

Authors:  Shigeru Matsumoto; Tsukasa Tominari; Chiho Matsumoto; Shosei Yoshinouchi; Ryota Ichimaru; Kenta Watanabe; Michiko Hirata; Florian M W Grundler; Chisato Miyaura; Masaki Inada
Journal:  Pharmaceuticals (Basel)       Date:  2018-01-20

Review 2.  Modulatory Effects of Plant Polyphenols on Bone Remodeling: A Prospective View From the Bench to Bedside.

Authors:  Vanessa Nicolin; Nunziatina De Tommasi; Stefania Lucia Nori; Fulvia Costantinides; Federico Berton; Roberto Di Lenarda
Journal:  Front Endocrinol (Lausanne)       Date:  2019-07-23       Impact factor: 5.555
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.