| Literature DB >> 25175065 |
A Jafarzadeh1, M Mohammadi-Kordkhayli2, R Ahangar-Parvin3, V Azizi3, H Khoramdel-Azad3, A Shamsizadeh4, A Ayoobi4, M Nemati2, Z M Hassan5, S M Moazeni5, M Khaksari6.
Abstract
The immunomodulatory effects of the IL-27 and IL-33 and the anti-inflammatory effects of ginger have been reported in some studies. The aim was to evaluate the effects of the ginger extract on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). In PBS-treated EAE mice the expression of IL-27 P28 was significantly lower whereas the expression of IL-33 was significantly higher than unimmunized control mice. In 200 and 300 mg/kg ginger-treated EAE groups the expression of IL-27 P28 and IL-27 EBI3 was significantly higher whereas the expression of IL-33 was significantly lower than PBS-treated EAE mice. The EAE clinical symptoms and the pathological scores were significantly lower in ginger-treated EAE groups. These results showed that the ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease.Entities:
Keywords: Clinical symptoms; Experimental autoimmune encephalomyelitis; Ginger; IL-27; IL-33
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Year: 2014 PMID： 25175065 DOI： 10.1016/j.jneuroim.2014.08.614
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478