| Literature DB >> 25174307 |
Maumita Bhattacharjee1, Jeannine Coburn2, Matteo Centola3, Sumit Murab1, Andrea Barbero3, David L Kaplan4, Ivan Martin5, Sourabh Ghosh6.
Abstract
Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm.Entities:
Keywords: Cartilage tissue; Developmental biology; Drug targets; In vitro models; Scaffolds; Signals
Mesh：
Year: 2014 PMID： 25174307 DOI： 10.1016/j.addr.2014.08.010
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470