OBJECTIVE: To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets. METHODS: In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used. RESULTS: The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules. CONCLUSION: The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.
OBJECTIVE: To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets. METHODS: In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used. RESULTS: The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules. CONCLUSION: The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.
Authors: Xue Han; Ding-Kun Zhang; Fang Zhang; Jun-Zhi Lin; Hong Jiang; Yang Lan; Xi Xiong; Li Han; Ming Yang; Chao-Mei Fu Journal: Pharmacogn Mag Date: 2017-07-19 Impact factor: 1.085