Christine F Skibola1, Susan L Slager2, Sonja I Berndt2, Tracy Lightfoot2, Joshua N Sampson2, Lindsay M Morton2, Dennis D Weisenburger2. 1. Department of Epidemiology, Comprehensive Cancer Center, University of Alabama, Birmingham, AL (CFS); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (SLS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (SIB, JNS, LMM); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (TL); Department of Pathology, City of Hope National Medical Center, Duarte, CA (DDW). cskibola@uab.edu. 2. Department of Epidemiology, Comprehensive Cancer Center, University of Alabama, Birmingham, AL (CFS); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (SLS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (SIB, JNS, LMM); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (TL); Department of Pathology, City of Hope National Medical Center, Duarte, CA (DDW).
Abstract
BACKGROUND: Acute lymphoblastic leukemia/lymphoma (ALL) in adults is a rare malignancy with a poor clinical outcome, and few reported etiologic risk factors. METHODS: We performed an exploratory pooled study of 152 ALL cases and 23096 controls from 16 case-control studies to investigate the role of medical history, lifestyle, family history, and occupational risk factors and risk of ALL. Age- race/ethnicity-, sex-, and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. RESULTS: An increased risk of ALL was found in those with a family history of a hematological malignancy (OR = 2.6, 95% CI = 1.22 to 5.54) and in leather (OR = 3.91, 95% CI = 1.35 to 11.35) and sewing/embroidery workers (OR = 2.92, 95% CI = 1.00 to 8.49). Consumers of alcohol had an increased risk of B-cell ALL (OR = 2.87, 95% CI = 1.18 to 6.95). CONCLUSIONS: The small number of statistically significant risk factors identified out of the 112 variables examined could be chance findings and will require further replication to assess their role in the etiology of adult ALL.
BACKGROUND: Acute lymphoblastic leukemia/lymphoma (ALL) in adults is a rare malignancy with a poor clinical outcome, and few reported etiologic risk factors. METHODS: We performed an exploratory pooled study of 152 ALL cases and 23096 controls from 16 case-control studies to investigate the role of medical history, lifestyle, family history, and occupational risk factors and risk of ALL. Age- race/ethnicity-, sex-, and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. RESULTS: An increased risk of ALL was found in those with a family history of a hematological malignancy (OR = 2.6, 95% CI = 1.22 to 5.54) and in leather (OR = 3.91, 95% CI = 1.35 to 11.35) and sewing/embroidery workers (OR = 2.92, 95% CI = 1.00 to 8.49). Consumers of alcohol had an increased risk of B-cell ALL (OR = 2.87, 95% CI = 1.18 to 6.95). CONCLUSIONS: The small number of statistically significant risk factors identified out of the 112 variables examined could be chance findings and will require further replication to assess their role in the etiology of adult ALL.
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Authors: Lindsay M Morton; Susan L Slager; James R Cerhan; Sophia S Wang; Claire M Vajdic; Christine F Skibola; Paige M Bracci; Silvia de Sanjosé; Karin E Smedby; Brian C H Chiu; Yawei Zhang; Sam M Mbulaiteye; Alain Monnereau; Jennifer J Turner; Jacqueline Clavel; Hans-Olov Adami; Ellen T Chang; Bengt Glimelius; Henrik Hjalgrim; Mads Melbye; Paolo Crosignani; Simonetta di Lollo; Lucia Miligi; Oriana Nanni; Valerio Ramazzotti; Stefania Rodella; Adele Seniori Costantini; Emanuele Stagnaro; Rosario Tumino; Carla Vindigni; Paolo Vineis; Nikolaus Becker; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Pierluigi Cocco; Lenka Foretova; Marc Maynadié; Alexandra Nieters; Anthony Staines; Joanne S Colt; Wendy Cozen; Scott Davis; Anneclaire J de Roos; Patricia Hartge; Nathaniel Rothman; Richard K Severson; Elizabeth A Holly; Timothy G Call; Andrew L Feldman; Thomas M Habermann; Mark Liebow; Aaron Blair; Kenneth P Cantor; Eleanor V Kane; Tracy Lightfoot; Eve Roman; Alex Smith; Angela Brooks-Wilson; Joseph M Connors; Randy D Gascoyne; John J Spinelli; Bruce K Armstrong; Anne Kricker; Theodore R Holford; Qing Lan; Tongzhang Zheng; Laurent Orsi; Luigino Dal Maso; Silvia Franceschi; Carlo La Vecchia; Eva Negri; Diego Serraino; Leslie Bernstein; Alexandra Levine; Jonathan W Friedberg; Jennifer L Kelly; Sonja I Berndt; Brenda M Birmann; Christina A Clarke; Christopher R Flowers; James M Foran; Marshall E Kadin; Ora Paltiel; Dennis D Weisenburger; Martha S Linet; Joshua N Sampson Journal: J Natl Cancer Inst Monogr Date: 2014-08