Literature DB >> 25173493

A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction.

Yuvaraj Dommaraju1, Dipak Prajapati.   

Abstract

A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.

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Year:  2014        PMID： 25173493     DOI： 10.1007/s11030-014-9547-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  28 in total

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2.  Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization.

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4.  Microwave-promoted catalyst- and solvent-free aza-Diels-Alder reaction of aldimines with 6-[2-(dimethylamino)vinyl]-1,3-dimethyluracil.

Authors:  Rupam Sarma; Manas M Sarmah; Dipak Prajapati
Journal:  J Org Chem       Date:  2012-01-30       Impact factor: 4.354

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Authors:  Xian Huang; Ruwei Shen; Tiexin Zhang
Journal:  J Org Chem       Date:  2007-02-16       Impact factor: 4.354

6.  Pyrrolnitrin and related pyrroles endowed with antibacterial activities against Mycobacterium tuberculosis.

Authors:  R Di Santo; R Costi; M Artico; S Massa; G Lampis; D Deidda; R Pompei
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7.  Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.

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Journal:  Chemistry       Date:  2009       Impact factor: 5.236

8.  Highly efficient chemoselective synthesis of polysubstituted pyrroles via isocyanide-based multicomponent domino reaction.

Authors:  Xiang Wang; Xiao-Ping Xu; Shun-Yi Wang; Weiqun Zhou; Shun-Jun Ji
Journal:  Org Lett       Date:  2013-08-07       Impact factor: 6.005

9.  A highly efficient and enantioselective intramolecular Cannizzaro reaction under TOX/Cu(II) catalysis.

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Review 10.  Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.

Authors:  Sébastien Deslandes; Stefan Chassaing; Evelyne Delfourne
Journal:  Mar Drugs       Date:  2009-12-01       Impact factor: 5.118
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  1 in total

1.  Hypervalent Iodine (III) Catalyzed Regio- and Diastereoselective Aminochlorination of Tailored Electron Deficient Olefins via GAP Chemistry.

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Journal:  Front Chem       Date:  2020-07-07       Impact factor: 5.221
  1 in total

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